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首页> 外文期刊>Journal of Cellular Physiology >Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice
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Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice

机译：Umbelliprenin显示了抗肿瘤、抗血管antimetastatic、抗炎和在4 t1肿瘤免疫刺激性活动

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摘要

Umbelliprenin (UMB) has shown various pharmacological properties in vitro. We investigated the antineoplastic and immunostimulatory effects of UMB in 4T1 mammary-tumor-bearing mice. Two-hundred microliter of UMB (12.5mg/ml) was intraperitoneally administrated to healthy and tumor-bearing female Balb/c mice for a period of 18 days. Data was analyzed using GraphPad Prism 5 software for Windows (version 5, La Jolla, CA). UMB caused a significant decrease in tumor size (P0.01). Serum interferon gamma (IFN) was augmented in both healthy and tumor-bearing animals (P0.01), and IL-4 declined in healthy animals (P0.01) treated with UMB. Expressions of Ki-67, VEGF, CD31, MMP2, MMP9, VCAM1, and NF-B were significantly decreased in tumors from UMB-treated animals (P0.001), whereas E-Cadherin and TNFR1 expressions were markedly increased (P0.001). The rates of liver and lung metastases in UMB-administrated animals were smaller compared to the control. UMB can potently inhibit tumor growth, angiogenesis, metastasis, and inflammation and potentiate an antitumor immune response in vivo. However, further investigations are required to evaluate the UMB mechanisms of action in cancerous cells.
机译：Umbelliprenin (UMB)显示不同体外药理属性。抗肿瘤药和调查免疫刺激性UMB 4 t1的影响mammary-tumor-bearing老鼠。微升UMB(12.5毫克/毫升)腹膜内的健康管理带有雌性Balb / c小鼠一段18天。Windows软件(版本5,拉霍亚,CA)。UMB导致肿瘤大小明显降低术中,0.01)。增强健康和肿瘤动物(术中,0.01)和il - 4拒绝在健康动物(术中;0.01)处理UMB。ki - 67、VEGF、CD31, MMP2, MMP9, VCAM1, NF-B显著减少肿瘤的UMB-treated动物(术中;0.001),而钙粘蛋白和TNFR1表达明显增加(术中,0.001)。在UMB-administrated动物肺转移相比较小的控制。抑制肿瘤生长、血管生成、转移、和炎症,加强抗肿瘤体内的免疫反应。调查需要评估UMB在癌细胞的作用机制。

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