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首页> 外文期刊>Journal of Cellular Physiology >EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis
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EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis

机译：EGFL7:主调节器的癌症发病机理,血管生成和骨一个新兴的中介体内平衡

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摘要

Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in many different cell types. EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion. Dysregulation of Egfl7 has been frequently found in several types of cancers, such as malignant glioma, colorectal carcinoma, oral and oesophageal cancers, gastric cancer, hepatocellular carcinoma, pancreatic cancer, breast cancer, lung cancer, osteosarcoma, and acute myeloid leukemia. In addition, altered expression of miR-126, a microRNA associated with Egfl7, was found to play an important role in oncogenesis. More recently, our study has shown that EGFL7 is expressed in both the osteoclast and osteoblast lineages and promotes endothelial cell activities via extracellular signal-regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3), and integrin signaling cascades, indicative of its angiogenic regulation in the bone microenvironment. Thus, understanding the role of EGFL7 may provide novel insights into the development of improved diagnostics and therapeutic treatment for cancers and skeletal pathological disorders, such as ischemic osteonecrosis and bone fracture healing.
机译：表皮生长因子以domain-containing蛋白7 (EGFL7),表皮的一员生长因子(EGF)——蛋白质家族,是一个强有力的血管生成因子表达了许多不同的细胞类型。控制血管血管生成在胚胎发生、器官形成和维持骨骼内稳态。功能主要通过调节信号通路(切口,整合素)和表皮生长因子受体级联。Egfl7在癌症生物学中扮演着关键角色调节肿瘤血管生成、转移和入侵。经常发现在几种类型的癌症,如恶性神经胶质瘤,大肠癌癌,口腔和食管的癌症,胃癌,肝细胞癌,胰腺癌,乳腺癌、肺癌、骨肉瘤急性髓系白血病(aml)。mir - 126的表达,microRNA联系在一起Egfl7,发现中扮演重要角色肿瘤形成。EGFL7是破骨细胞中表达和成骨细胞谱系,促进内皮细胞通过细胞外活动signal-regulated激酶(ERK)信号传感器和转录激活3 (STAT3),信号转导级联,指示性的血管生成调节的骨头微环境。EGFL7可能提供新颖的见解改进的诊断和发展治疗治疗癌症和骨骼病理障碍,如缺血性骨坏死和骨折愈合。

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