Is the secret for a successful aging to keep track of cancer pathways?

Tramontano Donatella; De Amicis Francesca

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Is the secret for a successful aging to keep track of cancer pathways?

机译：衰老是一个成功的秘密跟踪癌症的途径?

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A successful aging could be gained by life satisfaction, social functioning, or psychological resources and, definitely, by increasing resistance to diverse age-related pathologies. Nowadays, cancer can be considered an age-related disease since the incidence of most cancers increases with age, rising more rapidly beginning in midlife. Although adults with extended longevity are less likely to develop cancer, it is now emerging that aging and cancer share common molecular links, and thus targeting these mechanisms may be suitable to treat multiple disorders, for the prolonging of healthy aging. At present, one of the cornerstones of antiaging is hormone-replacement therapy to treat diseases associated with a state of age-related sex-hormone deficiency in women and men; however, many studies question the relationship of hormone replacement to cancer recurrence. Here, we discuss signaling and metabolic molecular crossroad linking aging and cancer. This is useful to argue about the current knowledge of prolongevity and druggable targets and to motivate specific intervention strategies that could modify practices of the aging population, activating multiple longevity pathways but keeping track of cancer pathways, thereby potentially preserving health status.

机译：一个成功的老化可以通过生活满意度、社会功能,或者心理资源,绝对增加抵抗不同的年龄病态。一种与年龄相关的疾病的发病率大多数癌症随年龄增长,进一步升高迅速在中年开始。与延长寿命的可能性更小患上癌症,现在新兴衰老和癌症的共同分子链接,因此针对这些机制可能是合适的治疗多种疾病,延长的健康老龄化。基础抗衰老激素替代疗法治疗疾病与状态有关与年龄有关的女性性激素不足和男人;激素替代与癌症的关系递归。代谢分子连接衰老和十字路口癌症。prolongevity和制药的知识目标和激励具体干预策略可以修改实践的老化人口,激活多个长寿途径但是跟踪癌症通路,从而可能保持健康状态。

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来源
《Journal of Cellular Physiology》 |2018年第11期|8467-8476|共10页
作者
Tramontano Donatella; De Amicis Francesca;
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作者单位

Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy;

Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy;

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正文语种英语
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关键词
FKBP12 Rapamycin Complex Associated Protein 1; Hormone Replacement Therapy; cellular metabolismCancer Pathwayhormonal disorderMiddle AgedEndocrine System DiseasesAGEING RESISTANCEInsulin-Like Growth Factor IAgingAMP-Activated Protein KinasesCornerstonesCancerrecurrent cancerCell Aging;

机译：FKBP12雷帕霉素相关的复杂的蛋白质1;激素替代疗法;细胞metabolismCancer Pathwayhormonal disorderMiddleAgedEndocrine系统DiseasesAGEINGRESISTANCEInsulin-Like生长因子IAgingAMP-Activated蛋白质老化;

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Is the secret for a successful aging to keep track of cancer pathways?

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