Two controls of cell proliferation underlie cancer relapse

Pardee Arthur B.; Li Chiang J.

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Two controls of cell proliferation underlie cancer relapse

机译：两个控制细胞增殖的基础癌症复发

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Much progress has been made in understanding the basis of cancer. Current therapies can effectively shrink tumors. But they frequently relapse, metastasize to other locations, and are lethal. Effective therapies are very much needed for preventing this relapse. Creation of a eukaryotic organism commences with one original stem cell, a fertilized egg, which multiplies and differentiates. Mutations of normal stem cells can produce cancer stem cells (CSC). These cells may resist chemotherapy, proliferate, and produce new tumors. Human chorionic gonadotrophin (hCG) is composed of two proteins (alpha and beta) that bind to the cell membrane and activate a number of intracellular pathways. hCG has been shown to activate the proliferation of cancer stem cells. Cyclin dependent regulation of the adult cells is created in normal differentiation and replaces the hCG regulation of stem cells. To selectively kill the cancer stem cells conventional cancer therapies could be followed with a therapy based on inactivating human chronic gonadotrophin (HCG). For example chemically modified prostaglandins like RU486 prevent binding of the unmodified steroid to hCG and inactivate hCG.

机译：在理解方面取得了巨大的进展癌症的基础。有效缩小肿瘤。复发,转移至其他地方,致命的。防止复发。真核生物与原有一个开始干细胞,一个受精卵,繁殖区分。可以产生癌症干细胞(CSC)。可以抵抗化疗、增殖并产生新肿瘤。由两个蛋白(α和β)与细胞膜结合并激活一个数字细胞内的通路。激活癌症干细胞的增殖。成年细胞的细胞周期素依赖监管创造了在正常分化和替换干细胞的hCG监管。杀死癌症干细胞常规癌症疗法可以遵循治疗的基础在人类长期的促性腺激素灭活(HCG)。前列腺素像RU486防止绑定的修改的类固醇hCG和灭活hCG。

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来源
《Journal of Cellular Physiology》 |2018年第11期|8437-8440|共4页
作者
Pardee Arthur B.; Li Chiang J.;
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作者单位

Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA;

Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA;

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原文格式 PDF
正文语种英语
中图分类
关键词
Human Chorionic Gonadotropin; Stem Cells; recurrent cancerNeoplastic Stem CellsRegulation (biology)Cell Proliferationcyclin dependent kinase inhibitor 1HIRA genemetastasiscancer therapyMifepristoneTumours;

机译：人体绒毛膜促性腺激素;干细胞;复发cancerNeoplastic茎CellsRegulation(生物学)细胞Proliferationcyclin依赖激酶抑制剂1希拉genemetastasiscancer;

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2. Anti-cancer activity of Tonglian decoction against esophageal cancer cell proliferation through regulation of the cell cycle and PI3K/Akt signaling pathway [J] . Yongsen Jia, Lijuan Qin, Chunhua Jiang, 中医科学杂志（英文） . 2015,第002期
3. Anti-cancer activity of Tonglian decoction against esophageal cancer cell proliferation through regulation of the cell cycle and PI3K/Akt signaling pathway [J] . Yongsen Jia, Lijuan Qin, Chunhua Jiang, 中医科学杂志(英文) . 2015,第002期
4. 再発小細胞肺癌（sensitive relapse and refractory relapse） [J] . 村上晴泰肺癌 . 2015,第5期

机译：再発小细胞肺癌（sensitive relapse and refractory relapse）
5. The search for substance: a quest for the identity-conditions of evidence-based medicine and some comments on Djulbegovic, B., Guyatt, G. H. & Ashcroft, R. E. (2009) Cancer Control, 16, 158-168. [J] . Loughlin M Journal of evaluation in clinical practice . 2009,第6期

机译：寻求实质性：寻求循证医学的身份条件，并对Djulbegovic，B.，Guyatt，G. H.＆Ashcroft，R. E.（2009）Cancer Control，16，158-168发表评论。
6. Where is the wisdom? II - Evidence-based medicine and the epistemological crisis in clinical medicine. Exposition and commentary on Djulbegovic, B., Guyatt, G. H. & Ashcroft, R. E. (2009) Cancer Control, 16, 158-168. [J] . Silva SA, Wyer PC Journal of evaluation in clinical practice . 2009,第6期

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7. Enhancement of Hepatocyte Function Through Heterotypic Cell-Cell Interactions Using E-Cadherin-Expressing NIH3T3 Cells [C] . Akira Ito, Takehiko Kiyohara, Yoshinori Kawabe, Annual and International Meeting of the Japanese Association for Animal Cell Technology . 2010

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8. A comparison of conventional PI-Control, PI-Control with decoupling, and dynamic matrix control. [D] . Unterbrink, Byron Bernard. 1998

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Two controls of cell proliferation underlie cancer relapse

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