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首页> 外文期刊>Journal of Cellular Physiology >Aerobic exercise, but not metformin, prevents reduction of muscular performance by AMPk activation in mice on doxorubicin chemotherapy
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Aerobic exercise, but not metformin, prevents reduction of muscular performance by AMPk activation in mice on doxorubicin chemotherapy

机译：有氧运动,但不是二甲双胍,阻止通过AMPk减少肌肉性能激活小鼠对阿霉素化疗

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Doxorubicin (DOX) is a chemotherapy agent widely used in clinical practice, and it is very efficient in tumor suppression, but the use of DOX is limited by a strong association with the development of severe muscle atrophy and cardiotoxicity effects. Reversion or neutralization of the muscular atrophy can lead to a better prognosis. Recent studies have proposed that the negative effect of DOX on skeletal muscle is linked to its inhibition of AMP‐activated protein kinase (AMPk), a key mediator of cellular metabolism. On the basis of this, our goal was to evaluate if aerobic exercise or metformin treatment, activators of AMPk, would be able to attenuate the deleterious effects on skeletal muscle induced by the DOX treatment. C57BL6 mice received either saline (control) or DOX (2.5?mg/kg body weight) intraperitoneally, twice a week. The animals on DOX were further divided into groups that received adjuvant treatment in the form of moderate aerobic physical exercise (DOX+T) or metformin gavage (300?mg/body weight/day). Body weight, metabolism, distance run, muscle fiber cross‐sectional area (CSA), and protein synthesis and degradation were assessed. We demonstrated that aerobic training, but not metformin, associated with DOX increased the maximal aerobic capacity without changing muscle mass or fiber CSA, rescuing the muscle fatigue observed with DOX treatment alone. This improvement was associated with AMPk activation, thus surpassing the negative effects of DOX on muscle performance and bioenergetics. In conclusion, aerobic exercise increases AMPk activation and improved the skeletal muscle function, reducing the side effects of DOX.
机译：阿霉素化疗(阿霉素)是一个广泛的代理应用于临床实践,它非常有效的肿瘤抑制,但使用阿霉素是有限的通过一个强大的协会严重的肌肉萎缩和发展毒性的影响。肌肉萎缩导致的中和更好的预后。建议阿霉素的负面影响骨骼肌的抑制有关AMP激活的蛋白激酶(AMPk)应承担的一个关键中介细胞新陈代谢。这一点,我们的目标是评估如果有氧锻炼或二甲双胍治疗,活化剂AMPk,能够减弱有害对骨骼肌的影响由阿霉素诱导的治疗。(控制)或阿霉素(2.5 ?腹腔内,每周两次。阿霉素被进一步分成组接受辅助治疗的形式温和的有氧体育锻炼(阿霉素+ T)或二甲双胍填喂法(300 ?体重、代谢,距离跑,肌肉纤维横截面积应承担(CSA)和蛋白质合成和降解进行了评估。有氧训练,但不是二甲双胍,与阿霉素最大有氧增加不改变肌肉或纤维的能力CSA,拯救观察到的肌肉疲劳阿霉素治疗。与AMPk活化,从而超越阿霉素对肌肉性能的负面影响和生物能疗法。锻炼增加AMPk活化和改善骨骼肌功能,减少阿霉素的影响。

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