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首页> 外文期刊>Journal of Cellular Physiology >Recombinant human hepatocyte growth factor provides protective effects in cerulein‐induced acute pancreatitis in mice
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Recombinant human hepatocyte growth factor provides protective effects in cerulein‐induced acute pancreatitis in mice

机译：重组人肝细胞生长因子提供保护作用cerulein诱导急性胰腺炎小鼠

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摘要

Acute pancreatitis is a multifactorial disease associated with profound changes of the pancreas induced by release of digestive enzymes that lead to increase in proinflammatory cytokine production, excessive tissue necrosis, edema, and bleeding. Elevated levels of hepatocyte growth factor (HGF) and its receptor c‐Met have been observed in different chronic and acute pancreatic diseases including experimental models of acute pancreatitis. In the present study, we investigated the protective effects induced by the recombinant human HGF in a mouse model of cerulein‐induced acute pancreatitis. Pancreatitis was induced by 8 hourly administrations of supramaximal cerulein injections (50?μg/kg, ip). HGF treatment (20?μg/kg, iv), significantly attenuated lipase content and amylase activity in serum as well as the degree inflammation and edema overall leading to less severe histologic changes such as necrosis, induced by cerulein. Protective effects of HGF were associated with activation of pro‐survival pathways such as Akt, Erk1/2, and Nrf2 and increase in executor survival‐related proteins and decrease in pro‐apoptotic proteins. In addition, ROS content and lipid peroxidation were diminished, and glutathione synthesis increased in pancreas. Systemic protection was observed by lung histology. In conclusion, our data indicate that HGF exerts an Nrf2 and glutathione‐mediated protective effect on acute pancreatitis reflected by a reduction in inflammation, edema, and oxidative stress.
机译：急性胰腺炎是一种多因素疾病与胰腺的深刻变化诱导释放消化酶所领导促炎细胞因子增加生产、过度的组织坏死、水肿和出血。地理因子(HGF)及其受体c了观察到在不同的慢性和急性胰腺疾病包括实验模型急性胰腺炎。调查引起的保护作用重组人类HGF的小鼠模型cerulein诱发急性胰腺炎。诱导了8小时的政府超大的cerulein注射(50 ?胶质瘤的治疗(20吗?减毒脂肪酶含量和淀粉酶活性血清炎症和程度整体水肿导致那么严重组织学改变如坏死,cerulein引起的。HGF的保护作用有关激活地理专业生存Akt等途径,遗嘱执行人Erk1/2, Nrf2和增加生存相关的蛋白质和减少箴凋亡蛋白。和脂质过氧化作用减弱谷胱甘肽合成增加胰腺。系统观察了肺保护组织学。HGF施加一个Nrf2,谷胱甘肽介导的保护作用在急性胰腺炎反映通过减少炎症、水肿和氧化应激。

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