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MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy

机译:微:相关性中风诊断,预后和治疗

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摘要

Stroke is a life‐threatening disease that accounts for a considerable burden of mortality in both developing and developed world. Identification of specific biomarkers for stroke and its outcomes can greatly contribute to improved care of patients. MicroRNAs (miRNAs) are known as novel biomarkers that could be used as diagnostic, prognostic, and therapeutic biomarkers. Various studies have shown that miRNAs have key roles in the pathogenesis of stroke, and its complications and outcomes. In addition, there is evidence showing that mesenchaymal stromal cell‐derived exosomes containing miRNAs can be used for monitoring and treatment of various diseases such as stroke. Here, we summarized various aspects of miRNA applications in different stages of stroke.
机译:中风是一个生命威胁的疾病,账户死亡率的相当大的负担发展中国家和发达国家。特定的生物标志物对中风及其结果可以大大有助于改善照顾病人。可以作为诊断的生物标志物,预后和治疗性生物标志物。研究表明,microrna的关键角色中风的发病机理,其并发症和结果。表明mesenchaymal基质细胞衍生出来的包含microrna可用于液监测和治疗各种疾病中风。microrna的应用程序在不同阶段的中风。

著录项

  • 来源
    《Journal of Cellular Physiology》 |2018年第2期|856-865|共10页
  • 作者单位

    Department of ImmunologyTehran University of Medical SciencesTehran,Iran;

    Department of Molecular BiotechnologyRoyan Institute for Biotechnology, ACECRIsfahan,Iran;

    Department of Immunology, School of MedicineIsfahan University of Medical SciencesIsfahan,IranFaculty of Bioscience EngineeringKatholieke Universiteit Leuve—KULeuvenHeverlee,BelgiumBiotechnology Research CenterMashhad University of Medical SciencesMashhad,IranNanotechnology Research CenterMashhad University of Medical SciencesMashhad,IranSchool of MedicineIsfahan University of Medical SciencesIsfahan,IranDepartment of Medical Biotechnology, School of MedicineMashhad University of MedicalDepartment of NeurologyUniversity of Florida College of MedicineGainesville,FloridaDepartment of Anatomical SciencesIsfahan University of Medical SciencesIsfahan,Iran;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类
  • 关键词

    Exosomes; MicroRNAs; Biological Markers;

    机译:Exosomes MicroRNAs;生物标记;

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