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首页> 外文期刊>Journal of Cellular Physiology >Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells
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Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

机译：Silibinin stimluates通过诱导细胞凋亡代的ROS和ER应激在人类绒毛膜癌的细胞

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摘要

Silibinin is a flavonolignan extracted from seeds of milk thistles. Traditionally, it has been used as a therapeutic agent for liver disorders, and now it is well‐known for its anti‐cancer effects. However, studies on anti‐cancer effects of silibinin on choriocarcinoma are very limited. Therefore, we performed proliferation and apoptosis assays to determine effects of silibinin on the viability of human choriocarcinoma (JAR and JEG3) cells. Our results showed that silibinin significantly inhibited proliferation and induced apoptosis in both JAR and JEG3 cells, and significantly increased reactive oxygen species (ROS) and lipid peroxidation. Moreover, silibinin disrupted mitochondrial function by inducing permeabilization of mitochondrial membrane potential and calcium ion efflux in JAR and JEG3 cells. Furthermore, silibinin‐induced apoptosis in choriocarcinoma cells via AKT, mitogen‐activated protein kinases (MAPK) and unfolded protein response (UPR) signal transduction. Collectively, our results suggest that silibinin is a novel therapeutic agent or dietary supplement for management of human placental choriocarcinomas.
机译：Silibinin flavonolignan从种子中提取牛奶蓟。作为肝脏疾病的治疗剂现在好还是出名的是它的抗癌症的效果。然而,研究抗癌症的影响绒毛膜癌silibinin非常有限。因此,我们核扩散和执行细胞凋亡分析确定的影响silibinin在人类的生存能力绒毛膜癌(JAR和JEG3)细胞。表明silibinin显著抑制在JAR增殖和诱导细胞凋亡和JEG3细胞,显著增加活性氧(ROS)和脂质过氧化反应。通过诱导线粒体功能线粒体膜的透化作用潜力和钙离子在JAR和JEG3流出细胞。绒毛膜癌细胞通过一种蛋白激酶,有丝分裂原激活蛋白激酶(MAPK)和展开的蛋白质反应(UPR)信号转导。治疗代理或silibinin是小说对管理人类的膳食补充剂胎盘绒毛膜癌。

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  • 来源
    《Journal of Cellular Physiology》 |2018年第2期|1638-1649|共12页
  • 作者

    Ham Jiyeon; Lim Whasun; Bazer Fuller W.Song Gwonhwa;

  • 作者单位

    Institute of Animal Molecular Biotechnology and Department of BiotechnologyKorea UniversitySeoul;

    Department of Biomedical SciencesCatholic Kwandong UniversityGangneung,Republic of Korea;

    Center for Animal Biotechnology and Genomics and Department of Animal ScienceTexas A & M;

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  • 正文语种 英语
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  • 关键词

    Choriocarcinoma; silybin; Apoptosis;

    机译：绒毛膜癌;silybin;细胞凋亡;

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