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首页> 外文期刊>Journal of Cellular Physiology >The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non‐cancer cells
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The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non‐cancer cells

机译：细胞核是不可逆转的的运动单元边界在癌症和非癌细胞

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摘要

Actomyosin stress fibers impinge on the nucleus and can exert compressive forces on it. These compressive forces have been proposed to elongate nuclei in fibroblasts, and lead to abnormally shaped nuclei in cancer cells. In these models, the elongated or flattened nuclear shape is proposed to store elastic energy. However, we found that deformed shapes of nuclei are unchanged even after removal of the cell with micro‐dissection, both for smooth, elongated nuclei in fibroblasts and abnormally shaped nuclei in breast cancer cells. The lack of shape relaxation implies that the nuclear shape in spread cells does not store any elastic energy, and the cellular stresses that deform the nucleus are dissipative, not static. During cell spreading, the deviation of the nucleus from a convex shape increased in MDA‐MB‐231 cancer cells, but decreased in MCF‐10A cells. Tracking changes of nuclear and cellular shape on micropatterned substrata revealed that fibroblast nuclei deform only during deformations in cell shape and only in the direction of nearby moving cell boundaries. We propose that motion of cell boundaries exert a stress on the nucleus, which allows the nucleus to mimic cell shape. The lack of elastic energy in the nuclear shape suggests that nuclear shape changes in cells occur at constant surface area and volume.
机译：肌动球蛋白应力纤维影响细胞核并且可以施加压缩力。抗压力量提出了延长成纤维细胞的细胞核,导致异常形核的癌细胞。拉长或核形状是扁平的提出了存储弹性能量。发现变形核的形状不变甚至在细胞的清除微观量解剖,光滑,细长原子核在成纤维细胞和异常形状的原子核在乳腺癌细胞。放松意味着核形状细胞不存储任何弹性能量传播,细胞核和细胞应力变形是耗散,而不是静态的。蔓延,原子核的偏差凸形状MDA量增加231 MB应承担的癌症细胞,但是减少MCF 10细胞。核和细胞形状的变化微型图象下层表明成纤维细胞只在变形在细胞细胞核变形形状和只在附近移动的方向单元边界。细胞核边界施加压力,允许核模拟细胞形状。核形状的弹性能量核细胞形状变化发生不断的表面积和体积。

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