The effect of substrate stiffness on cancer cell volume homeostasis

Wang Meng; Chai Na; Sha BaoyongGuo ManyunZhuang JianXu FengLi Fei

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The effect of substrate stiffness on cancer cell volume homeostasis

机译：衬底刚度对癌症细胞的影响体积内稳态

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摘要

Existing studies on the mechanism of cell volume regulation are mainly relevant to ion channels and osmosis in extracellular fluid. Recently, accumulating evidence has shown that cellular mechanical microenvironment also influences the cell volume. Herein, we investigated the regulation of substrate stiffness on the cell volume homeostasis of MCF‐7 cells and their following migration behaviors. We found that cell volume increases with increasing substrate stiffness, which could be affected by blocking the cell membrane anion permeability and dopamine receptor. In addition, the cell migration is significantly inhibited by decreasing the cell volume using tamoxifen and such inhibition effect on migration is enhanced by increasing substrate stiffness. The cell membrane anion permeability might be the linker between cellular mechanical microenvironment and cellular volume homeostasis regulation. This work revealed the regulation of substrate stiffness on cell volume homeostasis for the first time, which would provide a new perspective into the understanding of cancer metastasis and a promising anti‐cancer therapy through regulation of cell volume homeostasis.

机译：现有的研究机制的细胞体积监管主要是离子通道有关并在细胞外液渗透。越来越多的证据表明,细胞机械微环境也影响了细胞体积。调节基质细胞刚度体积MCF 7细胞及其应承担的体内平衡迁移后的行为。体积增加而增加衬底刚度,这可能是受到阻塞细胞膜离子渗透率和多巴胺受体。显著抑制细胞减少量使用他莫昔芬和这样的抑制效应在迁移是增强通过增加底物刚度。可能是细胞力学之间的链接微环境和细胞体积内稳态监管。基板刚度对细胞体积内稳态第一次,这将提供一个新的角度的理解癌症转移和一个有前途的抗癌症治疗通过调节细胞体积内稳态。

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来源
《Journal of Cellular Physiology》 |2018年第2期|1414-1423|共10页
作者
Wang Meng; Chai Na; Sha BaoyongGuo ManyunZhuang JianXu FengLi Fei;
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作者单位

The Key Laboratory of Biomedical Information Engineering of Ministry of EducationXi'an Jiaotong;

Department of RadiologyForth Military Medical UniversityXi'an,P. R. China;

School of Basic Medical ScienceXi'an Medical UniversityXi'an,P. R. ChinaBioinspired Engineering and Biomechanics Center (BEBC)Xi'an Jiaotong UniversityXi'an,P. R. ChinaSchool of Mechanical EngineeringXi'an Jiaotong UniversityXi'an,P. R. China;

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正文语种英语
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关键词
Cell Volume; Cell Locomotion; Cell MigrationHomeostasisRegulation (biology)inhibition effect;

机译：细胞体积;细胞运动、细胞MigrationHomeostasisRegulation(生物学)抑制效果;

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The effect of substrate stiffness on cancer cell volume homeostasis

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