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首页> 外文期刊>Journal of Cellular Physiology >Potential role of the Jagged1/Notch1 signaling pathway in the endothelial‐myofibroblast transition during BLM‐induced pulmonary fibrosis
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Potential role of the Jagged1/Notch1 signaling pathway in the endothelial‐myofibroblast transition during BLM‐induced pulmonary fibrosis

机译：Jagged1 / Notch1信号的潜在作用在内皮myofibroblast应承担的途径过渡期间BLM诱导肺纤维化

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摘要

Endothelial cell myofibroblast transition (EndoMT) is found during the process of bleomycin (BLM)‐induced pulmonary fibrosis in rats, and plays a very important role in sustaining inflammation and collagen secretion. Moreover, some studies have suggested that the Notch1 signaling pathway may be involved in the expression of α‐smooth muscle actin (α‐SMA) in pulmonary microvascular endothelial cells (PMVECs), a protein marker of EndoMT. Therefore, we aimed to investigate the expression level of α‐SMA and Notch1‐related signaling molecules in PMVECs from BLM‐induced rats and determine the relationship between the Notch1 signaling pathway and the expression of α‐SMA in PMVECs. We found that the expression levels of α‐SMA, Notch1, and Jagged1 were upregulated, while the expression levels of Dll4 were downregulated. Furthermore, there was a positive correlation between the expression of Jagged1 and the α‐SMA proteins in PMVECs, and NF‐κB was downregulated by decreasing the expression of Jagged1. In conclusion, the Jagged1/Notch1 signaling pathway is activated in PMVECs during the pathogenesis of BLM‐induced pulmonary fibrosis in rats, and it may induce α‐SMA expression via a non‐canonical pathway involving NF‐κB as the target molecule. The precise mechanism and the molecules involved in this signaling pathway need to be further elucidated.
机译：内皮细胞myofibroblast过渡(EndoMT)过程中发现博来霉素吗(BLM)诱导大鼠肺纤维化,应承担的在维持起着非常重要的作用炎症和胶原蛋白的分泌。一些研究表明,Notch1信号通路可能参与地理地理表达α平滑肌肌动蛋白(αSMA)肺微血管内皮细胞(PMVECs)蛋白质EndoMT的标志。我们旨在调查的表达水平α的SMA和Notch1相关信号分子PMVECs BLM的诱导大鼠和确定Notch1信号通路之间的关系和α的表达在PMVECs SMA。α的表达水平高SMA Notch1和Jagged1调节,而表达水平Dll4的表达下调。之间的正相关关系Jagged1表达式和αSMA蛋白质PMVECs,和NFκB被减少表达下调Jagged1的表达。Jagged1 / Notch1信号通路被激活PMVECs在BLM的发病机制诱导在大鼠肺纤维化,可能诱发αSMA表达通过一个非规范的途径涉及地理NFκB作为目标分子。精确的分子机制和参与这需要进一步的信号通路阐明。

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