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首页> 外文期刊>Journal of Cellular Physiology >Differential protein modulation by ketoprofen and ibuprofen underlines different cellular response by gastric epithelium
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Differential protein modulation by ketoprofen and ibuprofen underlines different cellular response by gastric epithelium

机译：微分调制ketoprofen和蛋白质布洛芬突显出不同的细胞反应通过胃上皮细胞

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Ketoprofen L‐lysine salt (KLS), is widely used due to its analgesic efficacy and tolerability, and L‐lysine was reported to increase the solubility and the gastric tolerance of ketoprofen. In a recent report, L‐lysine salification has been shown to exert a gastroprotective effect due to its specific ability to counteract the NSAIDs‐induced oxidative stress and up‐regulate gastroprotective proteins. In order to derive further insights into the safety and efficacy profile of KLS, in this study we additionally compared the effect of lysine and arginine, another amino acid counterion commonly used for NSAIDs salification, in control and in ethanol challenged human gastric mucosa model. KLS is widely used for the control of post‐surgical pain and for the management of pain and fever in inflammatory conditions in children and adults. It is generally well tolerated in pediatric patients, and data from three studies in 900 children indicate that oral administration is well tolerated when administered for up to 3 weeks after surgery. Since only few studies have so far investigated the effect of ketoprofen on gastric mucosa maintenance and adaptive mechanisms, in the second part of the study we applied the cMap approach to compare ketoprofen‐induced and ibuprofen‐induced gene expression profiles in order to explore compound‐specific targeted biological pathways. Among the several genes exclusively modulated by ketoprofen, our attention was particularly focused on genes involved in the maintenance of gastric mucosa barrier integrity (cell junctions, morphology, and viability). The hypothesis was further validated by Real‐time PCR.
机译：地理Ketoprofen L赖氨酸盐(吉隆坡),被广泛使用其镇痛疗效和耐受性L赖氨酸据报道,增加溶解度胃的宽容酮络芬和。最近的报告中,L赖氨酸应承担的成盐作用由于施加一gastroprotective效果其具体的应对能力非甾体抗炎药的诱导氧化应激和量调节gastroprotective蛋白质。进一步洞察安全性和有效性吉隆坡,在这项研究中我们另外赖氨酸和精氨酸的影响相比,另一个常见氨基酸平衡离子非甾体抗炎药成盐作用,控制和乙醇挑战人类的胃粘膜模型。广泛用于量手术后疼痛的控制和管理疼痛和发烧儿童和成人在炎症条件。它在小儿一般耐受性良好病人和数据从三个研究在900年孩子表明口服耐受性良好,管理3周后手术。到目前为止的酮络芬调查胃粘膜维护和适应性机制,我们在研究的第二部分应用提出的方法进行比较ketoprofen诱导和布洛芬诱导的基因表达谱来探索复合地理目标生物通路。在多个基因专门调制ketoprofen,我们尤为关注专注于基因参与维护胃粘膜屏障完整性(细胞连接,形态学和可行性)。通过实时PCR进一步验证。

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