...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Therapeutic potential of novel formulated forms of curcumin in the treatment of breast cancer by the targeting of cellular and physiological dysregulated pathways
【24h】

Therapeutic potential of novel formulated forms of curcumin in the treatment of breast cancer by the targeting of cellular and physiological dysregulated pathways

机译：治疗潜力的小说形式的制定姜黄素治疗乳腺癌的针对细胞和生理提供途径

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Breast cancer is among the most important causes of cancer related death in women. There is a need for novel agents for targeting key signaling pathways to either improve the efficacy of the current therapy, or reduce toxicity. There is some evidence that curcumin may have antitumor activity in breast cancer. Several clinical trials have investigated its activity in patients with breast cancer, including a recent trial in breast cancer patients receiving radiotherapy, in whom it was shown that curcumin reduced the severity of radiation dermatitis, although it is associated with low bioavailability. Several approaches have been developed to increase its absorption rate (e.g., nano crystals, liposomes, polymers, and micelles) and co‐delivery of curcumin with adjuvants as well as different conjugation to enhance its bioavailability. In particular, micro‐emulsions is an option for transdermal curcumin delivery, which has been reported to increase its absorption. Lipid‐based nano‐micelles is another approach to enhance curcumin absorption via gastrointestinal tract, while polymer‐based nano‐formulations (e.g., poly D, L‐lactic‐co‐glycolic [PLGA]) allows the release of curcumin at a sustained level. This review summarizes the current data of the therapeutic potential of novel formulations of curcumin with particular emphasis on recent preclinical and clinical studies in the treatment of breast cancer.
机译：乳腺癌是最重要的原因之一癌症相关死亡的女性。为小说代理商针对关键的信号途径是改善的功效目前的治疗,或减少毒性。一些证据表明,姜黄素抗肿瘤活动在乳腺癌。试验研究了其活动的病人与乳腺癌,包括最近的试验乳腺癌患者接受放疗,结果表明,姜黄素降低了严重的辐射皮炎,尽管它是生物利用度较低有关。方法已经开发,以增加其吸收速率(如纳米晶体,脂质体,聚合物,和胶束)和公司的交付姜黄素与佐剂以及不同结合来提高其生物利用度。具体来说,微乳剂是一种选择经皮的姜黄素交付,据报道,增加其吸收。纳米胶束是另一种方法来提高姜黄素通过胃肠道吸收,而基于聚合物量的纳米检测配方(如聚D, L乳酸量有限公司应承担的乙醇(PLGA)允许姜黄素的释放在一个持续的水平。回顾总结了当前的数据治疗的新配方的潜力姜黄素与最近特别强调临床前和临床研究治疗的乳腺癌。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号