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首页> 外文期刊>Journal of Cellular Physiology >The diversified function and potential therapy of ectopic olfactory receptors in non‐olfactory tissues
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The diversified function and potential therapy of ectopic olfactory receptors in non‐olfactory tissues

机译：多样化的功能和潜在的治疗异位嗅觉受体非嗅觉组织

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摘要

Olfactory receptors (ORs) are mainly distributed in olfactory neurons and play a key role in detecting volatile odorants, eventually resulting in the production of smell perception. Recently, it is also reported that ORs are expressed in non‐olfactory tissues including heart, lung, sperm, skin, and cancerous tissues. Interestingly, ectopic ORs are associated with the development of diseases in non‐olfactory tissues. For instance, ectopic ORs initiate the hypoxic ventilatory responses and maintain the oxygen homeostasis of breathing in the carotid body when oxygen levels decline. Ectopic ORs induce glucose homeostasis in diabetes. Ectopic ORs regulate systemic blood pressure by increasing renin secretion and vasodilation. Ectopic ORs participate in the process of tumor cell proliferation, apoptosis, metastasis, and invasiveness. Ectopic ORs accelerate the occurrence of obesity, angiogenesis and wound‐healing processes. Ectopic ORs affect fetal hemoglobin levels in sickle cell anemia and thalassemia. Finally, we also elaborate some ligands targeting for ORs. Obviously, the diversified function and related signal pathway of ectopic ORs may play a potential therapeutic target in non‐olfactory tissues. Thus, this review focuses on the latest research results about the diversified function and therapeutic potential of ectopic ORs in non‐olfactory tissues.
机译：嗅觉受体(ORs)主要分布在嗅觉神经元和发挥关键作用检测挥发性气味,最终结果生产的气味感知。口服补液盐也报道,表达非必经嗅觉组织包括心脏、肺、精子、皮肤和癌变组织。有趣的是,异位口服补液盐相关联疾病的发展非嗅觉组织。低氧通气反应和维护颈动脉氧稳态呼吸时身体含氧量下降。诱发糖尿病的葡萄糖稳态。口服补液盐监管系统性血压增加肾素分泌和血管舒张。口服补液盐异位参与肿瘤的过程细胞增殖、凋亡、转移和侵袭性。出现肥胖、血管生成和伤口的愈合过程。镰状细胞性贫血和血红蛋白的水平地中海贫血。口服补液盐配体的目标。多样化的功能和相关的信号通路异位的口服补液盐可能会扮演一个潜在的治疗目标进入非非嗅觉组织。最新研究成果综述多样化的功能和治疗潜在的口服补液盐异位非嗅觉组织。

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