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首页> 外文期刊>Journal of Cellular Physiology >NAD + + : A big player in cardiac and skeletal muscle remodeling and aging
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NAD + + : A big player in cardiac and skeletal muscle remodeling and aging

机译：NAD + +:心脏和骨骼的大玩家肌肉重塑和老化

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摘要

In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and anti‐aging molecule. A paper in science by Zhang et al. ([Zhang, H., 2016]) has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al. ([Cox, M. J., 2002]) demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. ([Cox, M. J., 2002]) also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD+ has a profound anti‐aging and anti‐oxidant effects, its effect on humans and use as a dietary supplement needs more exploration.
机译：在过去的十年里,NAD +已获得的重要性其抗氧化和有益的影响抗衰老的分子。et al。([张,H。2016])描述了NAD +补充时,改善肌肉萎缩症小鼠通过改善线粒体函数。作者以提高小鼠的寿命。艾尔。([考克斯·m·J。,2002])证明了心脏影响的NAD +减轻慢性心脏通过线粒体氧化还原状态机制的失败。考克斯et al。([考克斯·m·J。,2002])也证明了NAD +提供的饮用水,改善心脏体积松弛过载心力衰竭模型。深远的抗衰老和抗氧化剂应承担的后果,它影响人类和作为膳食补充剂需要更多的探索。

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