Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes‐associated protein

Dai Li‐Na; Yan Jun‐Kai; Xiao Yong‐TaoWen JieZhang TianZhou Ke‐JunWang YangCai Wei

首页> 外文期刊>Journal of Cellular Physiology >Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes‐associated protein

【24h】

Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes‐associated protein

机译：丁酸盐刺激人体肠道的生长平滑肌细胞的激活是的应承担相关的蛋白质

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Intestinal smooth muscle cells play a critical role in the remodeling of intestinal structure and functional adaptation after bowel resection. Recent studies have shown that supplementation of butyrate (Bu) contributes to the compensatory expansion of a muscular layer of the residual intestine in a rodent model of short‐bowel syndrome (SBS). However, the underlying mechanism remains elusive. In this study, we found that the growth of human intestinal smooth muscle cells (HISMCs) was significantly stimulated by Bu via activation of Yes‐Associated Protein (YAP). Incubation with 0.5?mM Bu induced a distinct proliferative effect on HISMCs, as indicated by the promotion of cell cycle progression and increased DNA replication. Notably, YAP silencing by RNA interference or its specific inhibitor significantly abolished the proliferative effect of Bu on HISMCs. Furthermore, Bu induced YAP expression and enhanced the translocation of YAP from the cytoplasm to the nucleus, which led to changes in the expression of mitogenesis genes, including TEAD1, TEAD4, CTGF, and Cyr61. These results provide evidence that Bu stimulates the growth of human intestinal muscle cells by activation of YAP, which may be a potential treatment for improving intestinal adaptation.

机译：肠道平滑肌细胞扮演至关重要在肠道结构的重塑中的作用和功能性肠切除术后适应。最近的研究表明,补充丁酸(Bu)有助于补偿扩张肌层的残余在一个啮齿动物模型的短肠肠综合症(SBS)。仍然是难以捉摸的。人类肠道平滑肌细胞的增长(HISMCs)大大刺激了布鲁里溃疡通过激活是的相关蛋白质(笨蛋)。孵化与0.5 ?对HISMCs增殖的影响,如所示促进细胞周期进程增加的DNA复制。通过RNA干扰或其特定抑制剂显著地废除了增殖效果妈妈在HISMCs之。表达和增强狂吠的易位从细胞质到细胞核,导致有丝分裂发生基因的表达变化,包括TEAD1、TEAD4 CTGF, Cyr61。结果提供证据表明,布鲁里溃疡刺激人类肠道肌肉细胞的增长激活的狂吠,这可能是一个潜在的治疗改善肠道适应。

著录项

来源
《Journal of Cellular Physiology》 |2018年第4期|3119-3128|共10页
作者
Dai Li‐Na; Yan Jun‐Kai; Xiao Yong‐TaoWen JieZhang TianZhou Ke‐JunWang YangCai Wei;
展开▼
作者单位

Shanghai Key Laboratory of Pediatric Gastroenterology and NutritionShanghai Institute for Pediatric;

Department of Pediatric SurgeryShanghai Jiao Tong University School of MedicineKongjiang Road;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Intestines; Butyrates; HISM cell lineSmooth muscle cellCell activation;

机译：肠子,丁酸;HISM细胞lineSmooth肌肉cellCell激活;

相似文献

外文文献
中文文献

1. Dahuang Zhechong Pill （大黄庶虫丸） Containing Serum Inhibited Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells Proliferation by Inducing G1 Arrest Partly via Suppressing Protein Kinase C α-Extracellular Regulated Kinase 1/2 Signaling Pathway [J] . 刘娜, 刘俊田, 姬媛媛, 中国结合医学杂志：英文版 . 2012,第005期
2. Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines [J] . Ayako, Kobori, Shigeki, 世界胃肠病学杂志：英文版 . 2010,第019期
3. Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Catechin; Cell Line, Tumor; Ceramides; Drug Synergism; Enzyme Activation; Humans; Ibuprofen; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53;*脱噬作用; Caspase类; 儿茶素; 神经酰胺类; 药物协同作用; 酶激活; 布洛芬; 氧化性应激; 磷酰化; 前列腺肿瘤; 原致癌基因蛋白质 c-bcl-2 [J] . The Netherlands journal of medicine. . 2009,第6期

机译：Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Catechin; Cell Line, Tumor; Ceramides; Drug Synergism; Enzyme Activation; Humans; Ibuprofen; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53;*脱噬作用; Caspase类; 儿茶素; 神经酰胺类; 药物协同作用; 酶激活; 布洛芬; 氧化性应激; 磷酰化; 前列腺肿瘤; 原致癌基因蛋白质 c-bcl-2
4. Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究 [J] . Acta Anaesthesiologica Scandinavica . 2009,第10期

机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
5. PD98059对H2O2诱导的人乳腺癌细胞凋亡及相关蛋白的影响 The Effect of the PD98059 on H2O2 Induced Apoptosis and Associated Proteins of Human Breast Cancer Cells [J] . Hans Journal of Biomedicine . 2011,第1期

机译：PD98059对H2O2诱导的人乳腺癌细胞凋亡及相关蛋白的影响 The Effect of the PD98059 on H2O2 Induced Apoptosis and Associated Proteins of Human Breast Cancer Cells
6. Sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha(2) expression that is involved in cell scattering [O] . Liang, C.C., Chen, H.C., 陳鴻震 2014

机译：sustained activation of extracellular signal-regulated kinase stimulated by hepatocyte growth factor leads to integrin alpha(2) expression that is involved in cell scattering

Butyrate stimulates the growth of human intestinal smooth muscle cells by activation of yes‐associated protein

摘要

著录项

相似文献

相关主题

期刊订阅