Apigenin induces ROS‐dependent apoptosis and ER stress in human endometriosis cells

Park Sunwoo; Lim Whasun; Bazer Fuller W.Song Gwonhwa

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Apigenin induces ROS‐dependent apoptosis and ER stress in human endometriosis cells

机译：芹黄素产生ROS的依赖的细胞凋亡和ER压力在人类子宫内膜异位的细胞

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Apigenin is a plant‐derived flavonoid having antiproliferative, anti‐inflammatory, and anti‐angiogenic properties in chronic and metabolic diseases, and cancers. However, the functional role of apigenin remains to be identified in human endometriosis that is a benign inflammatory disease causing infertility, dysmenorrhea, dyspareunia, and chronic abdominal or pelvic pain. In the present study, we determined the effects of apigenin on two well‐established human endometriosis cell lines (VK2/E6E7 and End1/E6E7). Apigenin reduced proliferation and induced cell cycle arrest and apoptosis in the both endometriosis cell lines. In addition, it disrupted mitochondrial membrane potential (MMP) which was accompanied by an increase in concentration of calcium ions in the cytosol and in pro‐apoptotic proteins including Bax and cytochrome c in the VK2/E6E7 and End1/E6E7 cells. Moreover, apigenin treated cells accumulated excessive reactive oxygen species (ROS), and experienced lipid peroxidation and endoplasmic reticulum (ER) stress with activation of the unfolded protein response (UPR) regulatory proteins. Furthermore, the apigenin‐induced apoptosis in endometriosis cells was regulated via the ERK1/2, JNK, and AKT cell signaling pathways. Taken together, apigenin is a potential novel therapeutic agent to overcome current limitations in the treatment to endometriosis.

机译：芹黄素是一个植物派生的类黄酮抗增殖、抗炎症应承担的和在慢性和抗血管生成应承担的属性代谢疾病和癌症。芹黄素还有待的功能作用识别在人类子宫内膜异位良性的炎性疾病引起不孕,痛经、性交困难和慢性腹部或骨盆疼痛。芹黄素的影响在两个决定建立人类子宫内膜异位症细胞线(VK2 / E6E7和End1 / E6E7)。增殖和诱导细胞周期阻滞和细胞凋亡在子宫内膜异位症细胞系。此外,它扰乱了线粒体膜潜在的(MMP)是伴随着一个中的钙离子浓度的增加胞质和pro凋亡蛋白包括伯灵顿,VK2 / E6E7和细胞色素cEnd1 / E6E7细胞。累积过多的活性氧(ROS),经验丰富的脂质过氧化和与激活内质网(ER)压力展开的蛋白质反应(UPR)监管蛋白质。细胞凋亡在子宫内膜异位是监管通过ERK1/2、物和AKT细胞信号通路。小说治疗克服当前代理限制在治疗子宫内膜异位。

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《Journal of cellular physiology.》 |2018年第4期|3055-3065|共11页
作者
Park Sunwoo; Lim Whasun; Bazer Fuller W.Song Gwonhwa;
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作者单位

Institute of Animal Molecular BiotechnologyKorea UniversitySeoul,Republic of Korea;

Department of Biomedical SciencesCatholic Kwandong UniversityGangneung,Republic of Korea;

Center for Animal Biotechnology and Genomics and Department of Animal ScienceTexas A&M;

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正文语种英语
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关键词
apigenin; Endometriosis; ApoptosisCell Cycle CheckpointsMitochondria;

机译：芹黄素;子宫内膜异位症;ApoptosisCell周期;

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Apigenin induces ROS‐dependent apoptosis and ER stress in human endometriosis cells

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