Myeloid‐derived suppressor cells: Important contributors to tumor progression and metastasis

Safarzadeh Elham; Orangi Mona; Mohammadi HamedBabaie FarhadBaradaran Behzad

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Myeloid‐derived suppressor cells: Important contributors to tumor progression and metastasis

机译：骨髓衍生应承担的抑制细胞:重要贡献者肿瘤进展和转移

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Myeloid‐derived suppressor cells (MDSCs) are traditionally considered among the major components of the immunosuppressive tumor microenvironment (TME). However, there is currently increasing evidence indicating that MDSCs in addition to suppression of immune surveillance is also involved in an array of non‐immunological functions like augmenting metastatic potential of tumor cells. Indeed, MDSCs can promote metastasis in animal models and cancer patients through promoting premetastatic niche formation, tumor angiogenesis and invasion. Moreover, MDSC frequency and function have been associated with progressive disease and correlated with clinical outcome. This review will summarize and discusses the data demonstrating the role for MDSCs in tumor metastasis.

机译：骨髓衍生抑制细胞(MDSCs)传统上认为是主要的免疫抑制肿瘤的组件微环境(时差)。目前越来越多的证据表明MDSCs除了免疫抑制监测也参与的数组非免疫功能增强转移性肿瘤细胞的潜力。MDSCs可以促进动物模型和转移通过促进premetastatic癌症患者利基市场的形成,肿瘤血管生成和入侵。此外,MDSC频率和功能与进步的疾病和有关与临床相关的结果。总结和讨论了数据吗展示MDSCs在肿瘤的作用转移。

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来源
《Journal of Cellular Physiology》 |2018年第4期|3024-3036|共13页
作者
Safarzadeh Elham; Orangi Mona; Mohammadi HamedBabaie FarhadBaradaran Behzad;
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作者单位

Immunology Research CenterTabriz University of Medical SciencesTabriz,Iran;

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原文格式 PDF
正文语种英语
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关键词
Tumor Microenvironment; Neoplastic Cell; suppressor cellNeoplasm MetastasisTumor ProgressionMyeloid-Derived Suppressor CellsmetastasisCancerImmunologic SurveillanceProgressive Neoplastic DiseaseAngiogenesis;

机译：肿瘤微环境;肿瘤细胞抑制cellNeoplasm MetastasisTumorProgressionMyeloid-Derived抑制器CellsmetastasisCancerImmunologicSurveillanceProgressive肿瘤DiseaseAngiogenesis;

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Myeloid‐derived suppressor cells: Important contributors to tumor progression and metastasis

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