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首页> 外文期刊>Journal of Cellular Physiology >The combination of plasma fibrinogen and neutrophil lymphocyte ratio (F‐NLR) is a predictive factor in patients with resectable non small cell lung cancer
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The combination of plasma fibrinogen and neutrophil lymphocyte ratio (F‐NLR) is a predictive factor in patients with resectable non small cell lung cancer

机译：血浆纤维蛋白原和的结合中性粒细胞淋巴细胞比率(F NLR应承担的)是一个可切除的非患者的预测因素小细胞肺癌

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The prognostic value of inflammation indexes in non small cell lung cancer (NSCLC) was not established. Therefore, we assessed the clinical applicability of the F‐NLR score, which is based on fibrinogen (F) and the neutrophil‐lymphocyte ratio (NLR), and the glasgow prognostic score (GPS) to predict the prognoses of NSCLC patients. We retrospectively identified 515 patients with stage I/II/IIIA who underwent surgery at our institution, and evaluated their preoperative serum levels of CRP, albumin, fibrinogen, neutrophil count, and the lymphocyte count. The cut‐off values of the fibrinogen level and NLR were determined with receiver operating characteristic (ROC) curve. GPS was classified into three groups as previously described. The disease free survival (DFS) and overall survival (OS) were calculated by the Kaplan–Meier method. Categorical variables were compared using the χ 2 test. Survival curves were estimated using the Kaplan–Meier method, and the Cox proportional hazard model was used to assess the prognostic factors. The F‐NLR was significantly associated with sex ( p ?=?0.000), smoking history ( p ?=?0.014), lesion type ( p ?=?0.000), histologic type ( p ?=?0.000), T stage ( p ?=?0.000), venous invasion ( p ?=?0.000), lymphatic invasion ( p ?=?0.000), and TNM stage ( p ?=?0.000). The 5‐year DFS rates in F‐NLR groups 0, 1, and 2 were 46.7%, 36.4%, 30.1%, respectively ( p ?=?0.000), and the 5‐year overall survival (OS) rates in the above three groups were 52.0%, 39.8%, 32.1%, respectively ( p ?=?0.000). Multivariate analysis showed that venous invasion ( p ?=?0.036), lymph node metastasis ( p ?=?0.000), and F‐NLR ( p ?=?0.034) were independent prognostic factors for DFS. Age ( p ?=?0.015), venous invasion ( p ?=?0.024), lymph node metastasis ( p ?=?0.000), and F‐NLR ( p ?=?0.019) were independent prognostic factors for OS. Thus, F‐NLR was the independent prognostic factor for both the DFS and OS. And patients with a high‐risk preoperative F‐NLR group may benefit from adjuvant therapy by subgroup analysis. Our results demonstrated that F‐NLR, a novel inflammation‐based grading system, as well as the GPS, appeared to have value as a promising clinical predictor of the prognosis for the resectable non small cell lung cancer patients.
机译：炎症指标的预后价值非小细胞肺癌(NSCLC)不是建立。适用性的F NLR应承担的得分,这是基础在纤维蛋白原(F)和中性粒细胞淋巴细胞比(NLR),格拉斯哥预后评分系统(GPS)预测非小细胞肺癌患者的预后。我们回顾性515患者阶段I / II / iii a在我们接受手术的人机构,和他们术前评估血清c反应蛋白,白蛋白、纤维蛋白原中性白细胞计数、淋巴细胞计数。削减量的纤维蛋白原水平和NLR值确定与接收机操作吗特征(ROC)曲线。分成三组(如前所述)。无病生存(DFS)和总生存期kaplan meier (OS)计算的方法。分类变量使用χ2进行比较测试。kaplan meier方法,和Cox比例风险模型被用来评估预后的因素。与性(0.000 p = ?),吸烟史(p0.014 = ?),损伤类型(p ? = 0.000),组织学类型(p = ? 0.000), T台(0.000 p = ?),静脉0.000入侵(p = ?),淋巴入侵(p? = 0.000),和TNM阶段(p ? = 0.000)。5年DFS F必经NLR组0、1和2分别为46.7%、36.4%、30.1% (p = ? 0.000),和5年总生存期(OS)的利率以上三组分别为52.0%,39.8%,32.1%,分别为0.000 (p = ?)。表明,静脉入侵(0.036 p = ?),淋巴0.000节点转移(p = ?),和F NLR (p0.034 = ?)是独立的预后因素DFS。0.024 = ?),淋巴结转移(p = ? 0.000),和F NLR (0.019 p = ?)都是独立的操作系统的预后因素。DFS的独立预后因素和操作系统。术前F NLR集团可能受益于亚组分析的辅助治疗。结果表明,F高NLR在一部小说基于炎症所致的评分系统,以及作为一个有前途的GPS,似乎有价值临床预后的预测可切除的非小细胞肺癌患者。

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