Comparison of genome‐wide analysis techniques to DNA methylation analysis in human cancer

Soozangar Narges; Sadeghi Mohammad R.; Jeddi FarhadSomi Mohammad H.Shirmohamadi MasoudSamadi Nasser

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Comparison of genome‐wide analysis techniques to DNA methylation analysis in human cancer

机译：基因组的比较广泛的分析技术DNA甲基化分析在人类癌症

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DNA methylation was the first epigenetic modification to be detected in human cancers with specific relation to aberrant gene expression. Herein, DNA methylation analysis explains how epigenetic patterns affect gene expression level. Hypermethylation at tumor suppressor gene loci leads to increased tumorigenesis due to tumor suppressor gene silencing, whereas global hypomethylation of CpG islands (CGIs) is followed by genomic instability and aberrant activation of multiple oncogenes. Therefore, characterization of the genes which silenced or activated epigenetically in human tumor cells can improve our understanding of cancer biology. Different genome‐wide methodologies are applied to evaluate methylation status. Various commonly conducted techniques for this evaluation are reviewed in this paper. We provided comparative description of the procedures, advantages, and drawbacks of genome‐wide DNA methylation analysis methods and biological applications, to give information on selecting the appropriate method for different methylation studies.

机译：DNA甲基化是表观遗传修改被发现在人类癌症特定的异常基因表达有关。在此,DNA甲基化分析解释了表观遗传模式影响基因表达水平。在肿瘤抑制基因甲基化位点由于肿瘤导致增加肿瘤发生抑制基因沉默,而全球hypomethylation CpG岛(cgi)基因组不稳定性和异常的激活多个癌基因。的基因沉默或激活epigenetically在人类肿瘤细胞可以改善我们对癌症生物学的理解。基因组广泛应用方法来评估甲基化状态。技术评价进行了综述这篇论文。的程序、优点和缺点基因组DNA甲基化分析方法和生物应用,给信息选择合适的方法不同甲基化研究。

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来源
《Journal of Cellular Physiology》 |2018年第5期|3968-3981|共14页
作者
Soozangar Narges; Sadeghi Mohammad R.; Jeddi FarhadSomi Mohammad H.Shirmohamadi MasoudSamadi Nasser;
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作者单位

Department of Molecular Medicine, Faculty of Advanced Medical Sciences,Tabriz University of Medical;

Liver and Gastrointestinal Diseases Research CenterTabriz University of Medical SciencesTabriz,Iran;

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正文语种英语
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关键词
Tumor Suppressor Genes; Genomic Instability; EpigeneticsDNA MethylationCancerCancer Biology;

机译：肿瘤抑制基因;基因不稳定;EpigeneticsDNAMethylationCancerCancer生物学;

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Comparison of genome‐wide analysis techniques to DNA methylation analysis in human cancer

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