The inhibitory effect in Fraxinellone on oxidative stress‐induced senescence correlates with AMP‐activated protein kinase‐dependent autophagy restoration

Han Xiaojuan; Chen Honghan; Zhou JiaoTai HaoranGong HuiWang XiaoboHuang NingQin JianqiongFang TingtingWang FeiXiao Hengyi

首页> 外文期刊>Journal of Cellular Physiology >The inhibitory effect in Fraxinellone on oxidative stress‐induced senescence correlates with AMP‐activated protein kinase‐dependent autophagy restoration

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The inhibitory effect in Fraxinellone on oxidative stress‐induced senescence correlates with AMP‐activated protein kinase‐dependent autophagy restoration

机译：Fraxinellone在氧化的抑制作用应力诱导衰老与AMP激活的蛋白激酶应承担相关的自噬恢复

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As a natural metabolite of limonoids from Dictamnus dasycarpus , fraxinellone has been reported to be neuroprotective and anti‐inflammatory. However, its influence on cellular metabolism remains largely unknown. In the present study, we investigated the effect of fraxinellone on cellular senescence‐induced by oxidative stress and the potential mechanism. We found that fraxinellone administration caused growth arrest and certainly repressed the activity of senescence associated β‐galactosidase as well as the expression of senescence‐associated‐genes. Interestingly, this effect of fraxinellone is closely correlated with the restoration of impaired autophagy and the activation of AMPK. Notably, fraxinellone reacts in an AMPK‐dependent but mTORC1‐independent manner. Together, our study demonstrates for the first time that fraxinellone has the effect on senescence inhibition and AMPK activation, and supports the notion that autophagic mechanism is important for aging prevention. These findings expanded the list of natural compounds and will be potentially utilized for aging decay and/or AMPK activation.

机译：作为一个自然的柠檬苦素类似物的代谢物据报道,神经保护和抗炎症。细胞的新陈代谢在很大程度上仍是个未知数。目前的研究中,我们调查的影响fraxinellone在细胞衰老引起的氧化应激和潜在机制。发现fraxinellone政府造成的增长肯定逮捕和压抑活动相关的衰老β牛乳糖的表达衰老检测相关基因。fraxinellone效果密切相关恢复自噬和受损的AMPK激活。在一个AMPK依赖但mTORC1独立的方式。第一次fraxinellone有影响衰老抑制和激活AMPK,支持认为自噬机制重要的预防老化。天然化合物的列表,并将扩大和/或可能用于老化衰变AMPK活化。

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来源
《Journal of Cellular Physiology》 |2018年第5期|3945-3954|共10页
作者
Han Xiaojuan; Chen Honghan; Zhou JiaoTai HaoranGong HuiWang XiaoboHuang NingQin JianqiongFang TingtingWang FeiXiao Hengyi;
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作者单位

Key Laboratory of Natural Medicine and Clinical TranslationChinese Academy of SciencesChengdu,China;

Lab for Aging ResearchSichuan University and Collaborative Innovation CenterChengdu,China;

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正文语种英语
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关键词
AMP-Activated Protein Kinases; Autophagy; Oxidative StressfraxinelloneSenescence;

机译：活化蛋白激酶;自噬;氧化;

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The inhibitory effect in Fraxinellone on oxidative stress‐induced senescence correlates with AMP‐activated protein kinase‐dependent autophagy restoration

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