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首页> 外文期刊>Journal of Cellular Physiology >Mammalian target of rapamycin as a therapeutic target in osteoporosis
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Mammalian target of rapamycin as a therapeutic target in osteoporosis

机译：哺乳动物雷帕霉素靶治疗目标在骨质疏松症

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摘要

The mechanistic target of rapamycin (mTOR) plays a key role in sensing and integrating large amounts of environmental cues to regulate organismal growth, homeostasis, and many major cellular processes. Recently, mounting evidences highlight its roles in regulating bone homeostasis, which sheds light on the pathogenesis of osteoporosis. The activation/inhibition of mTOR signaling is reported to positively/negatively regulate bone marrow mesenchymal stem cells (BMSCs)/osteoblasts‐mediated bone formation, adipogenic differentiation, osteocytes homeostasis, and osteoclasts‐mediated bone resorption, which result in the changes of bone homeostasis, thereby resulting in or protect against osteoporosis. Given the likely importance of mTOR signaling in the pathogenesis of osteoporosis, here we discuss the detailed mechanisms in mTOR machinery and its association with osteoporosis therapy.
机译：雷帕霉素的机械的目标(mTOR)扮演在传感和整合大量关键的作用环境因素的调节有机体的增长,体内平衡,许多主要的细胞流程。它的角色在调节骨内稳态,揭示了骨质疏松症的发病机理。激活/抑制mTOR信号据报道,积极/消极调节骨骨髓间充质干细胞(综合)/成骨细胞介导的骨形成,应承担的脂肪形成的差异化,骨细胞体内平衡,破骨细胞介导的骨吸收,导致骨的变化体内平衡,从而导致或保护对骨质疏松症。mTOR信号的发病机理骨质疏松症,我们详细讨论机制mTOR机械及其协会与骨质疏松症的治疗。

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