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首页> 外文期刊>Journal of Cellular Physiology >Key‐genes regulating the liposecretion process of mature adipocytes
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Key‐genes regulating the liposecretion process of mature adipocytes

机译：关键基因调节的liposecretion过程成熟的脂肪细胞

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摘要

White mature adipocytes (MAs) are plastic cells able to reversibly transdifferentiate toward fibroblast‐like cells maintaining stem cell gene signatures. The main morphologic aspect of this transdifferentiation process, called liposecretion, is the secretion of large lipid droplets and the development of organelles necessary for exocrine secretion. There is a considerable interest in the adipocyte plastic properties involving liposecretion process, but the molecular details are incompletely explored. This review analyzes the gene expression of MAs isolated from human subcutaneous fat tissue with respect to bone marrow (BM)‐derived mesenchymal stem cells (MSC) focusing on gene regulatory pathways involved into cellular morphology changes, cellular proliferation and transports of molecules through the membrane, suggesting potential ways to guide liposecretion. In particular, Wnt, MAPK/ERK, and AKT pathways were accurately described, studying up‐ and down‐stream molecules involved. Moreover, adipogenic extra‐ and intra‐cellular interactions were analyzed studying the role of CDH2, CDH11, ITGA5, E‐Syt1, PAI‐1, IGF1, and INHBB genes. Additionally, PLIN1 and PLIN2 could be key‐genes of liposecretion process regulating molecules transport through the membrane. All together data demonstrated that liposecretion is regulated through a complex molecular networks that are able to respond to microenvironment signals, cytokines, and growth factors. Autocrine as well as external signaling molecules might activate liposecretion affecting adipocytes physiology.
机译：白色的成熟脂肪细胞(MAs)是塑料细胞能可逆地transdifferentiate方向纤维母细胞类细胞维持干细胞的基因签名。分化转化的过程,称为liposecretion大型脂质分泌的水滴和细胞器的发展外分泌的必要条件。相当大的兴趣在脂肪细胞的塑料属性包括liposecretion过程,但是分子的细节是不完全的探索。本文分析了MAs的基因表达从人体皮下脂肪组织分离对骨髓(BM)派生间充质干细胞(MSC)专注于基因调控途径参与细胞形态变化,细胞的扩散和传输分子通过细胞膜,暗示潜在的方式指导liposecretion。特别是,Wnt、MAPK / ERK和AKT通路准确地描述,研究》量流分子参与。脂肪形成的额外的量和内部细胞间的相互作用分析研究的角色CDH2 CDH11,ITGA5, E‐Syt1排‐1 IGF1, and INHBB基因.此外,PLIN1和PLIN2关键基因liposecretion过程的调节分子通过膜的运输。证明liposecretion监管通过一个复杂的分子网络能够响应微环境信号,细胞因子和生长因子。外部信号分子可能会激活liposecretion影响脂肪细胞生理学。

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