Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker

Anwar Tarique; Sen Bijoya; Aggarwal SaveraNath RhisitaPathak NiteenKatoch AjayAiyaz MohamedTrehanpati NirupmaKhosla SanjeevRamakrishna Gayatri

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Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker

机译：不同调控基因表达静止与衰老和识别ARID5A作为静止相关联的标记

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In multicellular organisms majority of the cells remain in a non‐dividing states of either quiescence (reversible) or senescence (irreversible). In the present study, gene expression signatures unique to quiescence and senescence were identified using microarray in osteosarcoma cell line, U2OS. It was noted that certain genes and pathways like NOD pathway was shared by both the growth arrest conditions. A major highlight of the present study was increased expression of number of chemokines and cytokines in both quiescence and senescence. While senescence‐associated secretory phenotype (SASP) is well known, the quiescence‐associated secretory phenotype (QASP) is relatively unknown and appeared novel in this study. ARID5A, a subunit of SWI/SNF complex was identified as a quiescence associated gene. The endogenous expression of ARID5A increased during serum starved condition of quiescence. Overexpression of ARID5A resulted in more number of cells in G0/G1 phase of cell cycle. Further ARID5A overexpressing cells when subjected to serum starvation showed a pronounced secretory phenotype. Overall, the present work has identified gene expression signatures which can distinguish quiescence from senescence.

机译：在多细胞生物的细胞留在一个非分裂的状态静止(可逆)或衰老(不可逆)。表达独特的静止和签名使用微阵列在衰老被确定骨肉瘤细胞株,U2OS。某些基因和通路点头通路共享的同时增长逮捕条件。本研究的主要亮点增加数量的趋化因子和的表达式细胞因子在静止和衰老。虽然衰老检测分泌表型有关(SASP)是众所周知的,静止的关联分泌表型(QASP)是相对未知的和小说研究中出现。亚基被认定为瑞士/ SNF复杂静止相关联的基因。在血清ARID5A的表达增加饥饿的静止的条件。ARID5A导致更多数量的细胞G0 / G1期细胞周期。当受到血清overexpressing细胞饥饿表现出明显的分泌表现型。它可以确定基因表达签名区分静止和衰老。

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来源
《Journal of Cellular Physiology》 |2018年第5期|3695-3712|共18页
作者
Anwar Tarique; Sen Bijoya; Aggarwal SaveraNath RhisitaPathak NiteenKatoch AjayAiyaz MohamedTrehanpati NirupmaKhosla SanjeevRamakrishna Gayatri;
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作者单位

Institute of Liver and Biliary SciencesVasant Kunj,Delhi,India;

GenotypicBengaluru,Karnataka,India;

Centre for DNA Fingerprinting and DiagnosticsLaboratory BlockNampally 2,Hyderabad,Telangana,India;

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正文语种英语
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Gene Expression Profiles; Inflammasomes; Phenotypegrowth arrestSenescence;

机译：基因表达概要文件;Inflammasomes PhenotypegrowtharrestSenescence;

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Differentially regulated gene expression in quiescence versus senescence and identification of ARID5A as a quiescence associated marker

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