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首页> 外文期刊>Journal of Cellular Physiology >Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells
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Multidrug resistant lncRNA profile in chemotherapeutic sensitive and resistant ovarian cancer cells

机译：耐药lncRNA概要文件化疗敏感和耐药卵巢癌癌症细胞

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摘要

Most ovarian cancer patients are chemosensitive initially, but finally relapse with acquired chemoresistance. Multidrug‐resistance is the extremely terrible situation. The mechanism for the acquired chemoresistance of ovarian cancer patients is still not clear. LncRNAs have been recognized as the important regulator of a variety of biological processes, including the multidrug‐resistant process. Here, we carried out the lncRNA sequencing of the ovarian cancer cell line A2780 and the paxitaxel resistant cell line A2780/PTX which is also cross resistant to the cisplatin and epirubicin. Through integrating the published data with the cisplatin resistant lncRNAs in ovarian cancer cell line or ovarian cancer patients, 5 up‐regulated and 21 down‐regulated lncRNAs are considered as the multidrug‐resistant lncRNAs. By real‐time PCR analysis, we confirmed the 5 up‐regulated and 4 down‐regulated multidrug resistant lncRNAs were similarly changed in both the multidrug resistant ovarian cancer cell lines and the multidrug resistant colon cancer cell lines. Furthermore, we conducted the lncRNA‐mRNA co‐expression network to predict the potential multidrug resistant lncRNAs’ targets. Interestingly, the multidrug resistant genes ABCB1, ABCB4, ABCC3, and ABCG2 are all co‐expressed with lncRNA CTD‐2589M5.4. Our results provide the valuable information for the understanding of the lncRNA function in the multidrug resistant process.
机译：大多数卵巢癌患者是敏感的最初,但最终复发了药物抗性。非常可怕的情况。卵巢癌的获得药物抗性患者还不清楚。公认的重要调节器各种各样的生物过程,包括耐多药耐药过程。卵巢癌细胞的lncRNA测序行A2780和paxitaxel耐药细胞系A2780 / PTX也是交叉耐药顺铂和表柔比星。公布的数据与顺铂耐药lncRNAs卵巢癌细胞系或卵巢癌症患者,5的监管和21下来还是监管lncRNAs被认为是作为耐多药耐药lncRNAs。分析,我们证实了5的监管和4多药物耐药性lncRNAs下来量调节同样改变了在耐药卵巢癌细胞系和耐多药抗结肠癌细胞系。我们进行了lncRNA mRNA公司应承担的表达式网络预测潜在的多耐lncRNAs”目标。和ABCG2公司表示与lncRNA连续油管作业2589 m5.4。信息对lncRNA的理解函数在耐药过程中。

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