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首页> 外文期刊>Journal of Cellular Physiology >Exercise increases Rho‐kinase activity and insulin signaling in skeletal muscle
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Exercise increases Rho‐kinase activity and insulin signaling in skeletal muscle

机译：锻炼增加ρ的激酶活性和胰岛素信号在骨骼肌

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The effects of physical exercise on insulin signaling and glycemic homeostasis are not yet fully understood. Recent findings elucidated the positive role of Rho‐kinase (Rock) in increasing the glucose uptake through insulin receptor substrate‐1 (IRS1) phosphorylation in the skeletal muscle. Here, we explored the effects of short‐term exercise on Rock activity and insulin signaling. Fischer 344 rats (3 months old) were subjected to a short‐term swimming exercise for 2?hr per day for 5 days, with an overload corresponding to 1.5% of body weight. As expected, the exercised group had a reduced glycemia and increased insulin sensitivity. The contents of Rock1, Rock2, and Rock activity were improved in the skeletal muscle of the exercised rats. The contents of RhoA and RhoGEF, which are proteins involved in the Rock metabolism, were also increased in the skeletal muscle after exercise. These changes in the protein contents were accompanied by an increase in the insulin signaling pathway (pIRS1/pPDK/pAkt/pGSK3β/pAS160/GLUT4), Rock activity, and IRS1 phosphorylation at the 632/635 serine residues. On the other hand, when Rock was inhibited with the Y‐27632, the insulin sensitivity in response to exercise was impaired. Based on these findings, we conclude that the short‐term exercise increased both insulin sensitivity and glucose tolerance, through the increased Rock activity and pIRS1 (serine 632/635) mediated by Rock, in the skeletal muscle of Fischer 344 rats. These data represent an exercise‐mediated novel mechanism, suggesting an essential role of Rock activity in the insulin signaling and glucose homeostasis improvement.
机译：锻炼身体对胰岛素的影响信号和血糖稳态尚未完全理解。积极作用的ρ激酶(岩石)的增加通过胰岛素受体葡萄糖吸收1 (IRS1)磷酸化的底物量骨骼肌。短量项运动对岩石和胰岛素的活动信号。受到一个短学期游泳锻炼2？相应的体重的1.5%。行使集团预期降低血糖和胰岛素敏感性增加。Rock1内容、Rock2和岩石活动改善骨骼肌的运动老鼠。蛋白质参与岩石的新陈代谢,增加后的骨骼肌锻炼。伴随着增加胰岛素吗信号通路活动,IRS1磷酸化的632/635丝氨酸残基。抑制与Y量27632,胰岛素灵敏度响应运动受损。基于这些发现,我们得出这样的结论量短期锻炼增加胰岛素敏感性和葡萄糖耐量,通过岩石活动增加和pIRS1(丝氨酸632/635)由岩石,骨骼肌费舍尔344只老鼠。小说锻炼量调解机制,表明一个摇滚胰岛素的活动的重要作用信号和葡萄糖体内平衡的改善。

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