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首页> 外文期刊>Journal of Cellular Physiology >Sel1l knockdown negatively influences zebrafish embryos endothelium
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Sel1l knockdown negatively influences zebrafish embryos endothelium

机译：斑马鱼Sel1l击倒的负面影响胚胎内皮

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摘要

SEL1L (suppressor/enhancer of Lin‐12‐like) is a highly conserved gene associated with the endoplasmic reticulum‐associated degradation (ERAD) pathway and involved in mediating the balance between stem cells self‐renewal and differentiation of neural progenitors. It has been recently shown that SEL1L KO mice are embryonic lethal and display altered organogenesis. To better characterize the function of SEL1L in the early stages of embryonic development, we turned to the zebrafish model ( Danio rerio ). After exploring sel1l expression by RT‐PCR and in situ hybridization, we employed a morpholino‐mediated down‐regulation approach. Results showed extensive impairments in the vasculature, which supports the mice knock‐out findings.
机译：林SEL1L(抑制/增强剂的量12类)是一个高度保守的基因相关内质网相关的降解(ERAD)途径,参与调解干细胞自我更新和之间的平衡神经祖细胞的分化。最近表明,SEL1L KO小鼠胚胎致死和显示改变器官形成。SEL1L功能的早期阶段斑马鱼胚胎发育,我们转向model (Danio rerio)。表达式,RT PCR及原位杂交,我们使用一个吗啉代介导的监管的方法。脉管系统,支持的老鼠爆震检测结果。

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