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首页> 外文期刊>Journal of Cellular Physiology >Immunomodulatory effects of foreskin mesenchymal stromal cells on natural killer cells
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Immunomodulatory effects of foreskin mesenchymal stromal cells on natural killer cells

机译：免疫调节的影响包皮间充质基质细胞自然杀伤细胞

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摘要

Foreskin‐mesenchymal stromal cells (FSK‐MSCs) are immune‐privileged thus making them valuable immunotherapeutic cell product. Characterization of the relationship between FSK‐MSCs and natural killer (NK) cells is essential to improve cell‐based therapy. In the present study, we studied for the first time FSK‐MSCs‐NK interaction and showed that the result of such cross talk was robustly dependent on the type of cytokines (IL‐2, IL‐12, IL‐15, and IL‐21) employed to activate NK cells. Distinctly activated‐NK cells showed uneven cytotoxicity against FSK‐MSCs, triggering their death in fine. The expression of different cell‐surface ligands (CD112, CD155, ULPB‐3) and receptors (LAIR, KIRs) ensuring such interaction was altered following co‐culture of both populations. Despite their partial negative effect on NK cell proliferation, FSK‐MSCs boosted the capacity of activated NK‐cells to secrete IFN‐γ and TNF‐α. Moreover, FSK‐MSCs enhanced degranulation of NK cells, reinforced secretion of perforin and granzymes, while only modestly increased ROS production. On the other hand, FSK‐MSCs‐mediated expression of C1 and B9 serpins was significantly lowered in the presence of activated NK cells. Altogether, our results highlight major immunological changes following FSK‐MSCs‐NK interaction. Understanding these outcomes will therefore enhance the value of the therapeutic strategy.
机译：包皮量间充质基质细胞(移频键控量msc)免疫检测特权使他们有价值细胞免疫治疗产品。移频键控的msc和自然之间的关系杀伤(NK)细胞改善至关重要细胞的基础治疗。首次研究了移频键控量msc NK交互和显示,这样的结果相声是强劲依赖的类型细胞因子(IL 2,应承担IL 12,应承担IL 15日应承担和IL 21)用来激活NK细胞。激活NK细胞显示不均匀的细胞毒性针对移频键控量msc,引发他们的死亡很好。的表达不同的细胞表面配体(CD155 CD112 ULPB量3)和受体(巢穴,吉珥)确保这种交互是改变之后公司文化的人群。对NK细胞增殖,部分负面影响移频键控的msc刺激激活的能力NK‐cells to secrete IFN‐γ和TNF‐α.移频键控msc提高脱粒NK细胞,强化穿孔素的分泌和granzymes,只有适度增加活性氧的生产。另一方面,移频键控量msc介导的表达C1和B9 serpins显著降低激活NK细胞的存在。我们的研究结果强调主要的免疫学变化移频键控量后msc NK交互。因此,这些结果将提高价值的治疗策略。

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