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首页> 外文期刊>Journal of Cellular Physiology >Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients
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Analysis of secreted peptidome from omental adipose tissue in polycystic ovarian syndrome patients

机译：分析分泌peptidome网膜的脂肪组织在多囊性卵巢综合征病人

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Polycystic ovarian syndrome (PCOS) is a common endocrinopathy associated with increased risk of metabolic disorders. Prevalence of adiposity and obesity is greater in women suffering from PCOS. Moreover, adipose tissue dysfunction has been demonstrated in PCOS patients, particularly in abdominal adipose tissue. This dysfunction likely aggravates the metabolic and reproductive abnormalities. We used liquid chromatography‐mass spectrometry to compare the peptides secreted from PCOS and non‐PCOS abdominal adipose tissue. We detected 298 upregulated peptides and 31 downregulated peptides (absolute fold change?≥?2 and p? ?0.05). Twenty‐nine peptides were only detected in the PCOS group, while 18 were only detected in the control group. In addition, we demonstrate that these cleavage products are not degradation products of the proteasome based on previous studies reported. Gene Ontology enrichment and pathway analysis were performed to study differentially secreted peptides through their precursor proteins. We identified 12 peptides from 10 precursor proteins associated with PCOS, and 6 peptide sequences were located in the functional domains of their corresponding precursor proteins. These results provide a deeper understanding of adipose tissue‐derived peptides in PCOS for future functional studies.
机译：多囊卵巢综合征(PCOS)是一种常见的内分泌病与风险增加有关代谢紊乱。从PCOS女性肥胖是更大的痛苦。此外,脂肪组织功能障碍在PCOS患者,特别是在腹部脂肪组织。加剧了代谢和生殖异常。光谱法比较肽分泌从PCOS,非PCOS腹部脂肪组织。我们发现298调节肽和31表达下调肽(绝对的褶皱变化≥?和p ?检测PCOS组,18只在对照组中发现。证明这些乳沟产品不是降解产物的蛋白酶体的基础上以前的研究报道。浓缩和途径进行了分析研究不同分泌肽通过他们的前体蛋白。肽从10前体蛋白质有关PCOS,六肽序列在相应的功能域前体蛋白质。深入了解脂肪组织量肽在PCOS未来功能的研究。

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