The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

Majidinia Maryam; Aghazadeh Javad; Jahanban‐Esfahlani RanaYousefi Bahman

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The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

机译：Wnt /β连环蛋白通路应承担的角色在组织发展和再生医学

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Regenerative medicine is a translational field which combines tissue engineering and molecular biology to construct spare organs or help injured or defective tissues to regenerate or restore their normal functions. This is particularly important with specific organs such as heart, central nervous system, retina, or limbs which possess very limited regenerative capacity. As such, regenerative medicine has received peculiar attention in the last decade. In this regard, Wnt/β‐catenin signaling pathway has been subject to intensive research, since it plays many essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis. In this paper, we will briefly introduce Wnt/β‐catenin signaling pathway and discuss how it integrally contributes to both stem and cancer stem cell maintenance. Finally, we summarize the current understanding of the role of Wnt/β‐catenin signaling in the development and regeneration of heart, lung, liver, bone, and cartilage.

机译：再生医学是一个平移的领域结合组织工程和分子生物学建立备用器官或帮助受伤或有缺陷的组织再生或修复正常的功能。重要的与特定的器官如心脏、中枢神经系统、视网膜或四肢具有再生能力非常有限。这样,再生医学已经收到了特殊的在过去的十年的关注。Wnt /β连环蛋白信号通路应承担的主题密集的研究,因为它扮演了很多基本的监管角色祖细胞的命运,发展决策,扩散在胚胎发育期间,成年组织内稳态。简要介绍Wnt /β连环蛋白信号通路并讨论如何整合有助于两种干细胞和癌症干细胞维护。我们总结当前的理解Wnt /β连环蛋白信号应承担的角色发展和再生的心脏、肺、肝、骨和软骨。

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来源
《Journal of Cellular Physiology》 |2018年第8期|5598-5612|共15页
作者
Majidinia Maryam; Aghazadeh Javad; Jahanban‐Esfahlani RanaYousefi Bahman;
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作者单位

Stem Cell and Regenerative Medicine InstituteTabriz University of Medical SciencesTabriz,Iran;

Immunology Research CenterTabriz University of Medical SciencesTabriz,Iran;

Solid Tumor Research CenterUrmia University of Medical SciencesUrmia,IranDepartment of NeurosurgeryUrmia University of Medical SciencesUrmia,Iran;

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正文语种英语
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Stem Cells; Regenerative Medicine; RegenerationTissue EngineeringHistogenic ProcessWnt Signaling PathwayWnt Signaling Pathway PIDCanonical Wnt Signaling PathwayNoncanonical Wnt Signaling PathwayNotch and Wnt Signaling Pathwaynormal function;

机译：干细胞;再生医学;RegenerationTissue EngineeringHistogenicProcessWnt信号PathwayWnt信号通路PIDCanonical Wnt信号PathwayNoncanonicalWnt信号PathwayNotch和Wnt信号Pathwaynormal函数;

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The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine

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