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首页> 外文期刊>Journal of Cellular Physiology >Glucose enhances aggrecan expression in chondrocytes via the PKCα/p38‐miR141‐3p signaling pathway
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Glucose enhances aggrecan expression in chondrocytes via the PKCα/p38‐miR141‐3p signaling pathway

机译：葡萄糖提高aggrecan表达软骨细胞通过PKCα/ p38 miR141 3 p应承担的信号通路

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摘要

Aggrecan is a high molecular weight proteoglycan that plays a critical role in cartilage structure and the function of joints, providing intervertebral disc and cartilage with the ability to resist compressive loads. Aggrecan degradation in articular cartilage is a significant event in early‐stage osteoarthritis (OA). Currently, no effective treatment exists for OA other than pain relief. Dextrose ( D ‐glucose) prolotherapy has shown promising activity in the treatment of different musculoskeletal disorders, including OA. However, little is known about the molecular mechanism of the glucose effect in OA and on the regulation of chondrogenesis. We show for the first time that glucose upregulates aggrecan expression and subsequent chondrogenesis in ATDC5 cells. Moreover, we found that glucose‐induced aggrecan expression is mediated through the protein kinase Cα (PKCα)‐ and p38‐dependent pathway. As demonstrated by microRNA (miR) and luciferase analyses, the glucose‐induced PKCα/p38 signaling axis is responsible for downregulating miR141‐3p which targets to the 3′untranslated region of aggrecan. In summary, we show that glucose enhances chondrogenesis by upregulating aggrecan expression via the PKCα‐p38‐miR141‐3p signaling pathway. This result provides new insights into the mechanism of glucose on chondrogenesis.
机译：Aggrecan是一种高分子量蛋白多糖在软骨结构起着至关重要的作用和关节的功能,提供椎间盘和软骨抗压能力负荷。在关节软骨退化重大事件在早期阶段骨关节炎(OA)。OA除了缓解疼痛。葡萄糖)增生疗法显示有前途活动不同的治疗肌肉骨骼疾患,包括办公自动化。的分子机制所知甚少OA和监管的葡萄糖效应软骨形成。和葡萄糖上调aggrecan表达式随后在ATDC5细胞软骨形成。此外,我们发现,葡萄糖诱导aggrecan表达式是通过蛋白激酶介导的Cα(PKCα)和p38应承担相关的通路。证明了微rna (miR)和荧光素酶地理分析、葡萄糖诱导PKCα/ p38信号轴是负责表达下调miR141 3 p3 'untranslated地区哪些目标aggrecan。增强软骨形成,移植aggrecan通过PKC表达αp38 miR141应承担的3 p应承担的信号途径。葡萄糖对软骨形成的机制。

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