MicroRNA‐6869‐5p acts as a tumor suppressor via targeting TLR4/NF‐κB signaling pathway in colorectal cancer

Yan Shushan; Liu Guoyan; Jin ChengwenWang ZengfangDuan QuanhongXu JiangXu Donghua

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MicroRNA‐6869‐5p acts as a tumor suppressor via targeting TLR4/NF‐κB signaling pathway in colorectal cancer

机译：微rna量6869 5 p作为一个肿瘤抑制通过针对TLR4 / NFκB信号通路结肠直肠癌

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Many studies have implicated that microRNAs (miRNAs), as non‐coding RNAs, play important roles in the development and progression of colorectal cancer (CRC). However, little is known about the role of a newly identified miRNA, miR‐6869‐5p, in CRC. We aim to investigate the modifying effects and underlying mechanisms of miR‐6869‐5 in colorectal carcinogenesis and progression. Significantly reduced levels of miR‐6869‐5p were observed in both serum exosomes tumor tissue samples from patients with CRC. The prediction of targets of miR‐6869‐5p in databases of targetscan, microRNA. ORG and miRDBA revealed that toll‐like receptor 4 (TLR4) is a potential target for this miRNA. MiR‐6869‐5p could inhibit cell proliferation and the production of inflammatory cytokines (TNF‐α and IL‐6) in CRC cells via directly targeting TLR4. The protective effect of miR‐6869‐5p from colorectal carcinogenesis was dependent on TLR4/NF‐κB signaling pathway. In addition, the 3‐year survival was poor among CRC patients with decreased levels of miR‐6869‐5p in serum exosomes. Thus, miR‐6869‐5p may serve as a tumor suppressor in CRC, and serum exosomal miR‐6869‐5p is a promising circulating biomarker for the prediction of CRC prognosis.

机译：许多研究已经涉及,小分子核糖核酸(microrna),非编码rna,应承担的重要角色的开发和发展结直肠癌(CRC)。新发现的microrna的角色,在CRC miR量6869高5便士。修改效果和潜在的机制miR量6869 5在结直肠致癌作用进展。miR量6869量5 p观察血清液CRC患者肿瘤组织样本。预测的目标miR量6869 5 p在数据库中targetscan, microRNA。人数的类受体4 (TLR4)是一个潜在的这个microrna的目标。细胞增殖和生产炎性细胞因子(肿瘤坏死因子α和IL 6)应承担的CRC细胞直接针对TLR4通过。米尔效应量6869 5 p在大肠癌致癌作用依赖于TLR4 / NFκB信号通路。生存是穷人CRC患者降低血清miR量6869 5 p应承担的水平液。CRC的抑制,血清exosomal miR量6869 5便士是一个有前途的循环的生物标志物吗CRC预后的预测。

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来源
《Journal of Cellular Physiology》 |2018年第9期|6660-6668|共9页
作者
Yan Shushan; Liu Guoyan; Jin ChengwenWang ZengfangDuan QuanhongXu JiangXu Donghua;
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作者单位

Department of Gynecology and ObstetricsWeifang Hospital of Maternal and Child HealthWeifang,China;

Functional LaboratoryClinical Medicine College of Weifang Medical UniversityWeifang,China;

Department of Gastrointestinal and Anal Diseases SurgeryThe Affiliated Hospital of Weifang MedicalDepartment of Rheumatology and ImmunologyThe Affiliated Hospital of Weifang MedicalDepartment of DermatologyThe Affiliated Hospital of Weifang Medical UniversityWeifang,ChinaDepartment of RehabilitationThe Affiliated Hospital of Xuzhou Medical UniversityHuai'an,China;

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Tumor Suppressor Genes; Colorectal Cancer; Toll-Like Receptor 4Signal PathwaysMicroRNAsCancer of Colontumor tissue;

机译：肿瘤抑制基因;大肠癌;toll样受体4 PathwaysMicroRNAsCancer信号Colontumor组织;

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机译：Death receptor 5-mediated TNFR family signaling pathways modulate gamma-humulene-induced apoptosis in human colorectal cancer HT29 cells

MicroRNA‐6869‐5p acts as a tumor suppressor via targeting TLR4/NF‐κB signaling pathway in colorectal cancer

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