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首页> 外文期刊>Journal of Cellular Physiology >Four differentially methylated gene pairs to predict the prognosis for early stage hepatocellular carcinoma patients
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Four differentially methylated gene pairs to predict the prognosis for early stage hepatocellular carcinoma patients

机译：对四个不同甲基化基因预测预后的早期阶段肝细胞癌患者

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Hepatocellular carcinoma (HCC) was the second most common malignant tumor with a poor prognostic condition. We aimed to identify novel methylation signatures to predict HCC patients at their early stages. Differentially expressed methylated genes between HCC patients and normal liver tissues retrieved from TCGA were screened out by SAM. Genes highly related to patients’ survival were figured out by COX. The signatures that could identify relapse HCC patients were identified by the forwarding search algorithm. Besides, functional enrichment analysis was performed on the methylation genes in the signature. A total of 5,392 CPG sites that differentially methylated expressed were found out and 4,294 differentially expressed genes were obtained. A total of 197 genes among were associated with RFS of HCC patients at both stage I and stage II. Signature composed of 21 pairs was obtained to predict the prognostic situation by C‐index forward search method. The function of these genes was figured out by functional enrichment analysis. To summary, the signature composed of 21 gene pairs that can predict the prognostic situation of HCC patients at both stage I and stage II, provided a reference standard for the adjuvant therapy of HCC patients after surgery.
机译：肝细胞癌(HCC)是第二个最常见恶性肿瘤,预后较差条件。签名在早期预测肝癌患者阶段。肝细胞癌患者和正常肝组织之间从TCGA筛选检索由山姆。患者的生存是高度相关的基因算考克斯。识别复发肝癌患者了转发搜索算法。功能富集分析的甲基化基因签名。5392年的CPG甲基化不同的网站表示被发现和4294不同表达基因。基因在肝细胞癌与RFS有关病人在I期和II期。由21对得到预测预后情况,C的索引向前搜索方法。功能富集分析。总结,签名由21个基因对可以预测肝癌的预后情况病人在I期和II期,提供了一个参考标准的辅助治疗肝癌患者手术后。

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