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首页> 外文期刊>Archives of Andrology: An International Journal >Testis epidermal growth factor and spermatogenesis.
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Testis epidermal growth factor and spermatogenesis.

机译：睾丸表皮生长因子与生精。

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摘要

Epidermal growth factor (EGF) is a cytokine that promotes cell proliferation, regulates tissue differentiation, and modulates organogenesis. Although a rich source of EGF is the submaxillary gland, many tissues produce this cytokine, including the testis. Leydig cells are the principal source of EGF in the testis. On attainment of sexual maturation the germ cells, primarily spermatocytes and round spermatids, form EGF with the onset of spermatogenesis. EGF appears to be involved in the development of the testis and in spermatogenesis. The expression of the EGF gene in rat testis was determined by the application of the RT-PCR method and testis RNA as substrate. The results suggest that EGF produced by Leydig cells and germ cells may modulate spermatogenesis as an autocrine and/or paracrine factor.
机译：表皮生长因子（EGF）是一种促进细胞增殖，调节组织分化和调节器官发生的细胞因子。尽管上颌下腺是EGF的丰富来源，但许多组织都会产生这种细胞因子，包括睾丸。睾丸间质细胞是睾丸中EGF的主要来源。达到性成熟后，生殖细胞（主要是精细胞和圆形精子）会形成EGF，并开始生精。 EGF似乎参与了睾丸的发育和精子发生。应用RT-PCR方法，以睾丸RNA为底物，测定大鼠睾丸中EGF基因的表达。结果表明，Leydig细胞和生殖细胞产生的EGF可能将精子发生作为自分泌和/或旁分泌因子进行调节。

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