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首页> 外文期刊>EMBO Journal >TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
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TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

机译：TRBP,细胞PKR和hiv - 1病毒的监管机构表达式,与小礼帽和功能RNA silencing

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摘要

Dicer is a key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also has a role in the effector steps of RNA silencing. Apart from Argonautes, no proteins are known to associate with Dicer in mammalian cells. In this work, we describe the identification of TRBP (human immunodeficiency virus (HIV-1) transactivating response (TAR) RNA-binding protein) as a protein partner of human Dicer. We show that TRBP is required for optimal RNA silencing mediated by siRNAs and endogenous miRNAs, and that it facilitates cleavage of pre-miRNA in vitro. TRBP had previously been assigned several functions, including inhibition of the interferon-induced double-stranded RNA-regulated protein kinase PKR and modulation of HIV-1 gene expression by association with TAR. The TRBP-Dicer interaction shown raises interesting questions about the potential interplay between RNAi and interferon-PKR pathways.
机译：帽子是一个关键的酶参与了RNA干扰(RNAi)和microRNA microRNA的途径。所需的生物起源的microrna干扰rna (siRNAs),也有作用RNA沉默的效应的措施。阿尔戈号的船员,没有蛋白质关联哺乳动物细胞的帽子。描述TRBP(人类的识别免疫缺陷病毒(hiv - 1) transactivating响应(TAR) rna结合蛋白)作为一种蛋白质人类小礼帽的伙伴。所需的最优RNA沉默由siRNAs和内源性microrna,它促进pre-miRNA体外的乳沟。以前分配的几个函数,包括干扰素诱导的抑制双链RNA-regulated蛋白激酶PKR和调制的hiv - 1基因的表达与TAR。提出了有趣的问题潜在的RNAi和之间的相互作用interferon-PKR通路。

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