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首页> 外文期刊>EMBO Journal >Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion
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Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion

机译：Sec17p和酒花,在不同的陷阱复合物,调解网罗复杂的中断或组装融合

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摘要

SNARE functions during membrane docking and fusion are regulated by Sec1/Munc18 (SM) chaperones and Rab/Ypt GTPase effectors. These functions for yeast vacuole fusion are combined in the six-subunit HOPS complex. HOPS facilitates Ypt7p nucleotide exchange, is a Ypt7p effector, and contains an SM protein. We have dissected the associations and requirements for HOPS, Ypt7p, and Sec17/18p during SNARE complex assembly. Vacuole SNARE complexes bind either Sec17p or the HOPS complex, but not both. Sec17p and its co-chaperone Sec18p disassemble SNARE complexes. Ypt7p regulates the reassembly of unpaired SNAREs with each other and with HOPS, forming HOPS. SNARE complexes prior to fusion. After HOPS. SNARE assembly, lipid rearrangements are still required for vacuole content mixing. Thus, Sec17p and HOPS have mutually exclusive interactions with vacuole SNAREs to mediate disruption of SNARE complexes or their assembly for docking and fusion. Sec17p may displace HOPS from SNAREs to permit subsequent rounds of fusion.
机译：网罗在膜对接和融合功能受Sec1 / Munc18 (SM)监护人和Rab / Ypt GTPase效应器。酵母液泡融合相结合的six-subunit啤酒花复杂。核苷酸交换,是Ypt7p效应,包含一个SM蛋白。协会和啤酒花,要求Ypt7p,和Sec17/18p网罗复杂的装配。液泡网罗复合物绑定Sec17p或啤酒花复杂,但不能两者兼得。co-chaperone Sec18p拆卸网罗复合物。Ypt7p调节未配对的重组的陷阱与对方和啤酒花,形成啤酒花。在融合之前网罗复合物。网罗组装、脂质重组仍混合液泡所需内容。和啤酒花互斥的交互与液泡网罗调解中断网罗复合物或组装对接和融合。允许随后轮融合。

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