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首页> 外文期刊>Head and neck: Journal for the sciences and specialities of the head and neck >Expression of hedgehog signaling molecules in Merkel cell carcinoma.
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Expression of hedgehog signaling molecules in Merkel cell carcinoma.

机译：刺猬信号分子的表达默克尔细胞癌。

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摘要

BACKGROUND: The Hedgehog signaling pathway is important for human development and carcinogenesis in various malignancies. METHODS: One tissue microarray with triplets of 28 samples from 25 patients with Merkel cell carcinoma (MCC) was constructed. Six samples of normal skin and 5 samples of normal oral mucosa served as controls. All samples were analyzed immunohistochemically with antibodies directed against Sonic hedgehog, Indian hedgehog, Patched, Smoothened, Gli-1, Gli-2, and Gli-3. RESULTS: All investigated proteins were frequently and intensely overexpressed in MCCs (Sonic hedgehog, 93%; Indian hedgehog, 84%; Patched, 86%; Smoothened, 79%; Gli-1, 79%; Gli-2, 79%; Gli-3, 86%) compared with control samples. High levels of Patched and Indian hedgehog were significantly associated with an increase in patients overall (p = .015) and recurrence-free survival (p = .011), respectively. CONCLUSIONS: Our results indicate that the Hedgehog signaling pathway is strongly activated in MCC and thus may play a role in carcinogenesis.
机译：背景:刺猬信号通路对人类发展很重要致癌作用在各种恶性肿瘤。一个组织微阵列的三胞胎28个样本从25默克尔细胞癌患者(MCC)构造。正常口腔黏膜的样本作为控制。所有样品都是免疫组织化学分析与抗体针对声波刺猬,印度的刺猬,修补,平和,Gli-1Gli-2, Gli-3。蛋白质是频繁和强烈在监控化学品(声波刺猬,93%;印度的刺猬,84%;79%;与控制样本。印度刺猬都显著相关提高患者整体(p = .015)和recurrence-free生存(p = .011),分别。刺猬信号通路是强烈激活在MCC,因此可能扮演一个角色致癌作用。

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