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首页> 外文期刊>Head and neck: Journal for the sciences and specialities of the head and neck >Comprehensive IMRT plus weekly cisplatin for advanced head and neck cancer: the University of Wisconsin experience.
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Comprehensive IMRT plus weekly cisplatin for advanced head and neck cancer: the University of Wisconsin experience.

机译：综合强度+每周顺铂先进的头部和颈部癌症:大学威斯康辛州的经历。

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BACKGROUND: We retrospectively examined the treatment efficacy and toxicity profile of intensity-modulated radiotherapy (IMRT) plus concurrent weekly cisplatin chemotherapy in patients with locoregionally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A total of 57 patients with stage III or IV HNSCC were treated with IMRT and concurrent weekly cisplatin (dosed at 30 mg/m(2)) between November 2001 and May 2007. The median prescription dose to the gross tumor volume was 70 Gy (using 2.0-2.2 Gy daily fractions). RESULTS: In-field tumor control at 2 years was 89.1%, locoregional control was 85.5%, and overall survival was 86.9%. The median radiation dose delivered was 70 Gy. The mean dose intensity of cisplatin administered was 25.7 mg/m(2)/week. CONCLUSION: Comprehensive head and neck IMRT to 70 Gy delivered with weekly cisplatin chemotherapy (30 mg/m(2)) is feasible and generally well tolerated.
机译：背景:我们回顾性调查了治疗的疗效和毒性调强放射治疗(IMRT) +并发每周顺铂化疗患者局部区域先进的头颈部鳞状细胞癌(HNSCC)。共有57 HNSCC 3期或4期患者治疗使用强度和并发每周顺铂(前30毫克/米(2))在11月2001年和2007年5月。总值肿瘤体积是70 Gy(使用2.0 - -2.2 Gy每日分数)。肿瘤控制在2年为89.1%,局部区域控制为85.5%,和总生存期86.9%。Gy。管理为25.7毫克/米(2)/周。全面的头部和颈部放射至70 Gy每周交付与顺铂化疗(30毫克/米(2))是可行的,一般好容忍的。

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