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首页> 外文期刊>Chemical papers >Adsorption behavior of melphalan anti?ovarian cancer drug onto boron nitride nanostructures. Studying MTT assay: in vitro cellular toxicity and viability
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Adsorption behavior of melphalan anti?ovarian cancer drug onto boron nitride nanostructures. Studying MTT assay: in vitro cellular toxicity and viability

机译：美法仑的吸附行为反?抗癌药物在氮化硼纳米结构。研究MTT测定:体外细胞毒性和生存能力

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摘要

Ovarian cancer is believed as one of the most fatal reproductive cancers and melphalan has been known to treat this cancer as an intraperitoneal chemotherapeutic agent. Fortunately, nanotechnology enabled us to explore new approaches like nano vectors as drug nanocarriers to avoid or to diminish the collateral and secondary effects of anticancer drugs. Herein, boron nitride (BN) is disclosed as an effective nanocarrier for the delivery of melphalan anti-cancer drug. The performed density functional theory (DFT) studies showed good adsorption of melphalan on the surface of pure and Ge-doped boron nitride. In addition, the in vitro cellular toxicity and viability of boron nitride nanoparticles were examined on SKOV3 cancer cells. The inhibitory dose ID50 of BN nanoparticles confirmed that this material can be achieved as an acceptable vehicle for delivery of melphalan. Moreover, the effect of boron nitride nanoparticles (2 μg/mL) on the average growth curves of SKOV3 cancer cells showed a decrease of the MTT signal compared to the untreated cells and BN can reduce the metabolic activity of the performed cancer cells. Therefore, this fullerene can be regarded as a suitable sensor for detection of melphalan anti-cancer drug in biological systems. This study showed that BN nanoparticles have a clear inhibitory effect on the proliferation of SKOV3 ovarian cancer cells.
机译：卵巢癌被认为是最之一致命的生殖癌症与美法仑已知的治疗这种癌症的腹腔内化学治疗剂。纳米技术使我们探索新的方法如纳米载体药物的人们为了避免或减少抵押品副作用的抗癌药物。氮化硼(BN)是一种有效的披露nanocarrier美法仑的交付抗癌药物。泛函理论(DFT)的研究显示良好表面吸附的美法仑纯洁和Ge-doped氮化硼。体外细胞毒性和硼的可行性氮化硅纳米颗粒对SKOV3检查癌细胞。纳米粒子确认这种材料作为一个可接受的车辆交付美法仑。纳米颗粒(2μg / mL)平均增长曲线SKOV3癌细胞显示减少的MTT比未经处理的细胞信号和BN可以减少的代谢活动执行癌细胞。可以被看作是一个合适的传感器发现美法仑抗癌药物生物系统。纳米颗粒有明显的抑制作用卵巢癌SKOV3细胞的扩散。

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