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首页> 外文期刊>Chemical papers >Formulation and optimization of gefitinib?loaded nanosuspension prepared using a newly developed dendritic lipopeptide oligomer material
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Formulation and optimization of gefitinib?loaded nanosuspension prepared using a newly developed dendritic lipopeptide oligomer material

机译：制定和优化吉非替尼?使用新开发的nanosuspension准备树突lipopeptide低聚物材料

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Amino acid derived polypeptides are often biocompatible, and hence the materials of choice in nanoparticle formulations to avoid nanotoxicity and associated complications. A hydrophilic linear polypeptide γ-poly(l-glutamic acid) can form selfassembled nanoparticles only when made amphiphilic by chemical modification. Present work investigated pharmaceutical feasibility of a newly synthesized l-glutamic acid-based dendritic lipopeptide oligomer, which was found to be biocompatible and devoid of any inherent anticancer activity in vitro. Gefitinib, a poorly water-soluble anticancer drug, was used as the model drug to prepare an oligomeric nanosuspension by solvent evaporation–ultrasonication method. The formulation was optimized using response surface methodology and Box–Behnken model of design of experiments. The optimized gefitinibloaded oligomeric nanosuspension demonstrated acceptable particle-size distribution, surface morphology, colloidal stability, entrapment efficiency, and drug release profile. Overall, current work highlights competence of a newly synthesized dendritic lipopeptide oligomer for drug delivery applications.
机译：氨基酸多肽往往派生而来生物相容性,因此材料的选择在纳米颗粒配方nanotoxicity和相关并发症。亲水线性多肽γ保利(l-glutamic酸)可以形成selfassembled纳米颗粒当两性分子通过化学改性。现在工作调查制药新合成l-glutamic的可行性酸碱度树突lipopeptide低聚物,被发现生物相容性和没有任何固有的体外抗癌活性。抗癌药物的水溶性差,使用作为模型药物准备一个寡聚nanosuspension由溶剂evaporation-ultrasonication方法。使用响应面配方进行优化方法和Box-Behnken模型设计实验。寡聚nanosuspension证明可接受粒度分布、表面形态、胶体稳定性、截留效率,药物释放。强调了新合成的能力树突lipopeptide药物输送的低聚物应用程序。

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