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首页> 外文期刊>Chemical papers >Initial proteomic characterization of IMMODIN, commercially available dialysable leukocytes extract
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Initial proteomic characterization of IMMODIN, commercially available dialysable leukocytes extract

机译：初始IMMODIN蛋白质组学特征,商用dialysable白细胞提取

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One of the most significant public health challenges of the twenty-first century is the prevention and treatment of infectious diseases caused by various microorganisms, including resistant bacteria and viruses. With aging, there is a progressive alteration of the immune system and its responses that may result in immune senescence and immunodepression. Nevertheless, immune modulators can speed up recovery. IMMODIN~? is a commercially available dialysable leukocyte extract prepared from disintegrated white blood cells of healthy human donors. It is used clinically as a prophylactic or therapeutic agent when cell-mediated immunity plays a key role. This initial proteomic study was aiming to evaluate the polypeptide repertoire present in this immunologic preparation. Using our approach, we identified forty-eight unique proteins associated with blood cells or plasma. From them, twenty-eight were detected in at least two independent analyses of three IMMODIN~? preparations. The highest number of proteins was related to innate immunity. There were identified receptors for parasites or microbes that have the ability to recognize the invaders and initiate their inhibition or elimination. We also detected proteins associated with inflammatory response, including those having the potential to inhibit cytokines and treat the cytokine storm. There were found even proteins that can speed up recovery by regulating cell growth and repair.
机译：一个最重要的公共健康21世纪的挑战传染性疾病的预防和治疗由于各种微生物,包括抗细菌和病毒。是一个逐步改变免疫系统的吗及其可能导致的免疫响应衰老和免疫抑制。免疫调节剂可以加快复苏。IMMODIN ~ ?白细胞从解体提取做好准备白细胞人类健康的捐赠者。临床上用于预防或治疗细胞介导免疫起着关键时代理的角色。评估多肽剧目中这种免疫制剂。我们确定了48独特的蛋白质血液细胞或血浆。28在至少两个检测独立的分析三个IMMODIN ~ ?准备。先天免疫相关。受体的寄生虫和微生物识别能力入侵者并启动抑制或消除。与炎症反应相关的蛋白质,包括那些拥有潜在的抑制细胞因子和治疗细胞因子风暴。甚至发现了蛋白质,可以加快吗恢复通过调节细胞生长和修复。

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