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首页> 外文期刊>Journal of diabetes. >Metabolic risk factors among prediabetic individuals and the trajectory toward the diabetes incidence
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Metabolic risk factors among prediabetic individuals and the trajectory toward the diabetes incidence

机译：代谢在前驱糖尿病的危险因素个人和轨迹向糖尿病发病率

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Background This study investigates the trajectory of the risk factors of prediabetes progression to overt diabetes. Methods The study retrospectively investigated 1610 prediabetic individuals. The trajectory of metabolic indicators was investigated using the generalized estimated equation method with autoregressive working correlation structure through a linear model with the identity link function. Results During 15 years of follow-up, the trajectories of metabolic risk factors changed from 3 years before diabetes occurrence for fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG), 6 years for waist circumference (WC), 9 years for high-density lipoprotein cholesterol (HDL-C), and earlier for body mass index, triglyceride (TG), and TG:HDL ratio. It was shown that the differences in the trajectory of WC and HDL were stable after adjustment for other metabolic risk factors. The trajectories of FPG and 2hPG remained stable after considering multiple insulin resistance markers. Conclusions Deterioration of metabolic risk factor status can be a predictor of diabetes many years before its occurrence, but the abrupt change in plasma glucose is evident 3 years before diabetes mellitus onset. It seems that the HDL-C and WC trajectories are two independent predictors for diabetes incidence. It was also found that when the rising trend in plasma glucose starts, preventive strategies to lessen insulin resistance might not be efficient.
机译：本研究背景调查轨迹前驱糖尿病进展的危险因素明显的糖尿病。调查1610年前驱糖尿病的个体。代谢指标的轨迹使用广义估计研究自回归方程方法工作通过一个线性模型与相关结构身份链接功能。年的随访中,代谢的轨迹从3年前改变了糖尿病危险因素空腹血浆葡萄糖(台塑)和发生两个小时血浆葡萄糖(2高压天然气),6年的腰高密度的周长(WC), 9年脂蛋白,早些时候身体质量指数、甘油三酯(TG)和TG:高密度脂蛋白比率。轨迹WC和高密度脂蛋白是稳定的调整其他代谢危险因素。台塑的轨迹和2高压天然气保持稳定在考虑多个胰岛素抵抗标记。风险因素可以预测糖尿病状态多年前发生,但突然血糖的变化是显而易见的3年在糖尿病发病。高密度脂蛋白胆固醇和WC轨迹是两个独立的糖尿病发病率的预测因子。发现,当等离子体的上升趋势减少葡萄糖开始,预防策略胰岛素抵抗可能不是有效的。

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