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Compartmentalized supramolecular hydrogels based on viral nanocages towards sophisticated cargo administration

机译：区分基于超分子水凝胶在病毒nanocages向复杂的货物政府

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摘要

Introduction of compartments with defined spaces inside a hydrogel network brings unique features, such as cargo quantification, stabilization and diminishment of burst release, which are all desired for biomedical applications. As a proof of concept, guest-modified cowpea chlorotic mottle virus (CCMV) particles and complementary guest-modified hydroxylpropyl cellulose (HPC) were non-covalently crosslinked through the formation of ternary host-guest complexes with cucurbit[8] uril (CB[8]). Furthermore, CCMV based virus-like particles (VLPs) loaded with tetrasulfonated zinc phthalocyanine (ZnPc) were prepared, with a loading efficiency up to 99%, which are subsequently successfully integrated inside the supramolecular hydrogel network. It was shown that compartments provided by protein cages not only help to quantify the loaded ZnPc cargo, but also improve the water solubility of ZnPc to avoid undesired aggregation. Moreover, the VLPs together with ZnPc cargo can be released in a controlled way without an initial burst release. The photodynamic effect of ZnPc molecules was retained after encapsulation of capsid protein and release from the hydrogel. This line of research suggests a new approach for sophisticated drug administration in supramolecular hydrogels.
机译：引入部分定义空间在水凝胶网络带来独特的特性,如货物量化、稳定和分崩离析破裂释放,这就是一切理想的生物医学应用。的概念,guest-modified豇豆萎黄病的斑点病毒(CCMV)粒子和互补的guest-modified hydroxylpropyl纤维素(HPC)通过非共价交联吗三元主客体复合物的形成葫芦[8]uril (CB[8])。病毒样颗粒(一种)装载tetrasulfonated锌酞菁(ZnPc)准备,装载效率高达99%,哪些是随后成功集成在超分子水凝胶网络。结果表明,隔间提供蛋白质笼子里不仅有助于量化ZnPc加载货,也提高的水溶性ZnPc避免不受欢迎的聚合。一种连同ZnPc货物可以释放在一个没有一个初始破裂的控制方式释放。分子是封装后留存衣壳蛋白水凝胶和释放。这一研究表明一种新方法先进的药品监督管理局超分子水凝胶。

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