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Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug

机译：Mitochondria-based航母增强活体成像的碳量子点和交付抗癌药物

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The application of engineered bacteria-based drug delivery vehicles to treat cancer has been practiced for more than a century. Mitochondria, evolutionarily originated from bacteria, are ubiquitous, semi-autonomous cellular organelles. In this study, we present the first exploration of using mitochondria as a delivery system of carbon quantum dots (CQDs) for in vivo imaging and administration of the anticancer drug doxorubicin (DOX). The results show that mitochondria as carriers are compatible with CQD loading and preserve the optical properties of CQDs. Moreover, the mitochondria delivery system can improve the CQD bio-distribution in organs and prolong the retention time of CQDs after intravenous injection. Furthermore, mitochondria loaded with doxorubicin hydrochloride (Mito-DOX) show an enhanced therapeutic effect compared to free DOX. The mitochondria-based "aircraft" system may be a promising novel therapeutic platform with high potential for biological imaging and drug delivery to fight cancer and other diseases.
机译：设计基于细菌的药物中的应用运载工具治疗癌症练习了一个多世纪。起源于细菌进化无处不在,半自治的细胞细胞器。在这项研究中,我们提出第一个探索使用线粒体的交付系统碳量子点(cqd)体内成像和管理的抗癌药物阿霉素(阿霉素)。线粒体是运营商与CQD兼容加载和保存的光学特性cqd。可以提高CQD生物分布在器官和延长后cqd的保留时间静脉注射。含有盐酸阿霉素(Mito-DOX)显示一个增强治疗效果相比免费的强力霉素。系统可能是一个有前途的新颖的治疗平台具有高潜力的生物成像和药物对抗癌症和交付其他疾病。

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