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首页> 外文期刊>Canadian Medical Association Journal: Journal de l'Association Medicale Canadienne >Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus
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Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus

机译：发病的影响产妇的体重,,葡萄糖不宽容和脂质在婴儿出生体重女性没有妊娠(期)糖尿病

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Background: The delivery of excess maternal nutrients to the fetus is known to increase the risk of macrosomia, even among infants of women without gestational diabetes mellitus. With the current obesity epidemic, maternal adiposity and its associated effects on circulating adipokines and inflammatory proteins may now have a greater impact on fetal growth. We sought to evaluate the independent effects of maternal glycemia, lipids, obesity, adipokines and inflammation on infant birth weight.Methods: We included 472 women who underwent an oral glucose tolerance test in late pregnancy and were found not to have gestational diabetes; 104 (22.0%) had gestational impaired glucose tolerance. We also measured fasting levels of insulin, low- and high-density lipoprotein cholesterol, triglycerides, leptin, adiponectin and C-reactive protein. Obstetric outcomes were assessed at delivery.Results: The mean birth weight was 3481 g (standard deviation 493 g); 68 of the infants were large for gestational age. On multiple linear regression analysis, positive determinants of birth weight were length of gestation, male infant, weight gain during pregnancy up to the time of the oral glucose tolerance test, body mass index (BMI) before pregnancy and impaired glucose tolerance in pregnancy. Leptin, adiponectin and C-reactive protein levels were each negatively associated with birth weight. On logistic regression analysis, the significant metabolic predictors of having a large-for-gestational-age infant were BMI before pregnancy (odds ratio [OR] 1.16, 95% confidence interval [Cl] 1.05-1.27, per 1 kg/m2 increase), weight gain during pregnancy up to the time of the oral glucose tolerance test (OR 1.12, 95% Cl 1.05-1.19, per 1 kg increase) and leptin level (OR 0.50, 95% Cl 0.30-0.82, per 1 standard deviation change).Interpretation: Among women without gestational diabetes, maternal adiposity and leptin levels were the strongest metabolic determinants of having a large-for-gestational-age infant rather than glucose intolerance and lipid levels.
机译：背景:多余的孕产妇的交付的营养给胎儿增加巨大胎儿的风险,即使在婴儿的妇女无妊娠糖尿病。当前的肥胖症,孕产妇肥胖和对循环发病相关的影响和炎性蛋白可能现在有一个更大的对胎儿生长的影响。独立的影响产妇血糖、脂质,婴儿肥胖,发病和炎症出生体重。年末进行口服葡萄糖耐量试验发现怀孕和妊娠糖尿病;葡萄糖耐量。的胰岛素水平,低收入和高密度脂蛋白胆固醇、甘油三脂、瘦素,脂联素和c反应蛋白。在交付成果进行评估。平均出生体重3481克(标准差493克);胎龄。分析,出生体重的积极因素是妊娠期的长度,男婴儿,体重吗获得孕期口腔的时候葡萄糖耐量试验,身体质量指数(BMI)在怀孕前和葡萄糖耐量在怀孕。蛋白质水平负相关与出生体重。分析,重要的代谢的预测因素有一个large-for-gestational-age婴儿妊娠前体重指数(优势比1.16[或],95%置信区间(Cl) 1.05 - -1.27,每1 kg / m2增加),在怀孕期间体重增加了的口服葡萄糖耐量试验(或1.12,95%氯1.05 - -1.19,每增加1公斤)和瘦素级别(Cl 0.30 - -0.82或0.50,95%,每标准偏差变化)。没有妊娠糖尿病,母亲的肥胖和瘦素水平最强的代谢的决定因素large-for-gestational-age婴儿而不是葡萄糖和脂质水平。

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