Etomidate puts sickest patients at risk of adrenal crisis

Andrew J Hartle; Philip H Peel

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Etomidate puts sickest patients at risk of adrenal crisis

机译：依托咪酯对重病患者肾上腺的风险危机

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Wass and Arlt do not mention that certain anaesthetictechniques may increase patients' risk of adrenal crisis.Because the carboxylated imidazole induction agent etomidate causes fewer haemodynamic effects than other intravenous agents, it may be preferred for the sickest patients undergoing surgery. Its suppressive effects on the adrenocortical axis (by inhibiting 11 beta-hydroxylaseand 17 alpha-hydroxylase) have been known for30years, and ended its use for sedation in critical care units.Patients receiving etomidate should be closely monitored for postoperative adrenal crisis, and careful consideration given to hydrocortisone administration.

机译：Wass和某些Arlt没有提到anaesthetictechniques可能增加病人的风险肾上腺危象。咪唑诱导代理人依托咪酯引起更少比其他静脉血液动力学的影响代理,它可能是首选的病情最严重的时候病人接受手术。对肾上腺皮质轴(通过抑制的影响11 beta-hydroxylaseand 17α-羟化酶)众所周知for30years,结束了它的使用在重症监护单位镇静。接收依托咪酯应该严密监控术后肾上腺危象,小心考虑给予氢化可的松管理。

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来源
《BMJ: British medical journal》 |2012年第7882期|25-25|共1页
作者
Andrew J Hartle; Philip H Peel;
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作者单位

St Mary's Hospital, Imperial College Heatthcare NHSTrust, London W2 6HP, UK;

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原文格式 PDF
正文语种英语
中图分类医药、卫生;
关键词
Etomidate; At-risk; Adrenal crisissedationCytochrome P450 Family 17;

机译：P450家庭17;

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Etomidate puts sickest patients at risk of adrenal crisis

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