• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Ophthalmologica: International Journal of Ophthalmology=Journal International d'Ophtalmologie >The effect of intravitreal ranibizumab on the fellow untreated eye with subfoveal scarring due to exudative age-related macular degeneration.
【24h】

The effect of intravitreal ranibizumab on the fellow untreated eye with subfoveal scarring due to exudative age-related macular degeneration.

机译：的影响intravitreal初上的眼睛由于subfoveal疤痕治疗渗出性老年性黄斑变性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

AIM: Our purpose was to evaluate the possible effect of intravitreal ranibizumab on the fellow untreated eye with choroidal neovascularization (CNV) and subfoveal scarring associated with age-related macular degeneration (AMD). METHODS: A retrospective observational study was conducted. One hundred eighty-seven ranibizumab-treated patients diagnosed as having subfoveal CNV scarring in the untreated eye were compared with a control group of untreated unilateral subfoveal CNV scarring. Inclusion criteria concerning treated eyes in the ranibizumab group complied with the MARINA and ANCHOR studies. Demographic data, clinical course, visual acuity, fluorescein angiography and optical coherence tomography findings were evaluated. RESULTS: Clinical improvement was confirmed in 24% of the patients in the ranibizumab group and in only 12.9% of the controls. Improvement was noted as early as 2-4 months (2.83 + or - 0.75 months) after the initiation of treatment in the fellow eye compared with 33.25 + or - 9.43 months in the control group (p = 0.01; Mann-Whitney U test). Kaplan-Meier curves demonstrate the positive impact of ranibizumab on the visual acuity of the fellow untreated eye (p = 0.016; Log-Rank test). CONCLUSIONS: Ranibizumab might induce some therapeutic effect in selected cases of end-stage CNV scarring, which needs to be further examined. The VEGF levels in the compartments of the fellow eye of patients with age-related macular degeneration treated with ranibizumab need to be further evaluated.
机译：目的:我们的目的是评估成为可能intravitreal效果之初的家伙未经处理的眼睛与脉络膜新生血管形成(CNV)和subfoveal疤痕年龄相关性黄斑变性(AMD)。一个回顾性观察研究进行的。ranibizumab-treated病人诊断为subfoveal CNV治疗眼睛的疤痕与对照组相比,治疗单边subfoveal CNV疤痕。有关治疗眼睛的标准初集团遵守码头锚的研究。视力,荧光素血管造影和光学相干断层扫描结果评估。证实了在24%的病人初组只有12.9%的控制。几个月后(2.83 +或- 0.75个月)起始治疗的的眼睛相比之下,33.25 +或- 9.43个月对照组(p = 0.01;kaplan meier曲线展示积极的一面初对视力的影响的未经处理的眼睛(p = 0.016;结论:初可能诱发一些晚期的治疗效果在选定的情况下CNV疤痕,这需要进一步检查。VEGF水平隔间的家伙眼患者的年龄相关性黄斑变性治疗之初需要进一步的评估。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号