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首页> 外文期刊>Ophthalmologica: International Journal of Ophthalmology=Journal International d'Ophtalmologie >Deep sclerectomy versus trabeculectomy with low-dosage mitomycin C: four-year follow-up.
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Deep sclerectomy versus trabeculectomy with low-dosage mitomycin C: four-year follow-up.

机译：深层巩膜切除术和小梁切除术低剂量丝裂霉素C:四年随访。

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摘要

AIMS: To compare the long-term effects of low-dosage mitomycin C (MMC) in both deep sclerectomy (DSMMC) and trabeculectomy (TPMMC) on intraocular pressure (IOP). METHODS: Analysis of extended follow-up of data from a prospective clinical trial. Forty patients were originally randomised to undergo either DSMMC (19 eyes) or TPMMC (21 eyes). Follow-up was performed at postoperative day 1, weeks 1, 2 and 3, as well as months 1, 3, 6, 9, 12, 18, 24, 36 and 48. Two- to three-week data were not included in the statistical analysis. Postoperative complications, number of antiglaucoma medications and IOP were recorded at each visit. Complete (no medications) and qualified (with or without medications) successes were assessed at 2 target IOPs (< or =21 and < or =17 mm Hg) and evaluated by Kaplan-Meier curves. RESULTS: At 48 months, the mean IOP (+/- SD) was 17.6 +/- 3.4 and 17.8 +/- 3.6 mm Hg in the DSMMC and TPMMC eyes, respectively, a significant reduction from preoperative IOP in each group (p < 0.0005). Complete success was achieved at the < or =21 mm Hg target IOP in 10 (52.6%) and 14 (66.6%) eyes and qualified success in 15 (78.9%) and 18 (85.7%) eyes in the DSMMC and TPMMC groups, respectively. There were no differences in the Kaplan-Meier curves. Hypotony and shallow anterior chamber were significantly more frequent in the TPMMC group. CONCLUSIONS: Either procedure controlled IOP efficaciously at our endpoint. Low-dosage MMC can be considered a mild enhancement of deep sclerectomy IOP-lowering effect.
机译：目的:比较的长期影响低剂量丝裂霉素C (MMC)在深巩膜切除术(DSMMC)和小梁切除术(TPMMC)眼内压(IOP)。从未来的延长随访数据临床试验。随机接受要么DSMMC(19眼)TPMMC(21眼)。术后第一天,周1、2和3,以及月1、3、6、9、12、18、24、36和48。为期三周的数据没有包含在统计分析。并发症,antiglaucoma药物的数量在每一次访问记录和眼压。药物)和合格(有或没有药物)成功是2的目标IOPs(< = 21岁和<或= 17毫米汞柱)和评估kaplan meier曲线。平均眼压(+ / - SD)是17.6 + / - 3.4和17.8+ / - 3.6毫米汞柱DSMMC和TPMMC眼睛,分别显著减少术前眼压在每组(p < 0.0005)。圆满成功实现在< = 21毫米Hg目标眼压10(52.6%)和14(66.6%)的眼睛和合格的成功在15(78.9%)和18(85.7%)眼睛DSMMC和TPMMC组,分别。kaplan meier曲线。前房明显更频繁TPMMC组。眼压控制有效地在我们的端点。低剂量MMC可认为是温和的加强深层巩膜切除术IOP-lowering的效果。

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