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首页> 外文期刊>Ophthalmologica: International Journal of Ophthalmology=Journal International d'Ophtalmologie >Comparison of ocular surface side effects of topical travoprost and bimatoprost.
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Comparison of ocular surface side effects of topical travoprost and bimatoprost.

机译：比较眼表面的副作用局部travoprost bimatoprost。

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摘要

PURPOSE: To compare the subjective symptoms, conjunctival hyperemia, tearing response and conjunctival cytological changes secondary to topical administration of bimatoprost and travoprost for 6 months. METHODS: Newly diagnosed primary open-angle glaucoma patients were randomly prescribed bimatoprost (35 cases) or travoprost (42 cases). Two patients in each group were excluded because they did not appear at their appointments regularly. Thus, 33 and 40 patients completed the study in the bimatoprost and travoprost groups, respectively. Redness, itching, foreign-body sensation, pain and discomfort were assessed by a questionnaire, and patients were examined for conjunctival hyperemia. Schirmer's I and break-up time tests were performed, and impression cytology of conjunctiva was evaluated. RESULTS: Subjective symptoms were similar in both groups. The only subjective symptom that changed significantly was redness. The change in conjunctival hyperemia along the study period correlated with the patient-reported redness in both groups, being highest on day 30. Schirmer's test I and break-up time did not change with time and were similar in both groups. The impression cytology grade increased with time in both groups with the only significant difference between groups on day 90 (higher in the bimatoprost group). CONCLUSION: We observed conjunctival hyperemia as the most common side effect of bimatoprost and travoprost. Tear film functions were not affected by these drugs while cytological alterations were.
机译：目的:比较主观的症状,结膜充血,撕裂和响应继发于结膜细胞学变化局部bimatoprost和管理travoprost为6个月。原发性开角型青光眼患者随机规定bimatoprost(35例)或travoprost(42例)。被排除在外,因为他们没有出现在哪里他们经常约会。bimatoprost患者完成了研究分别和travoprost团体。疼痛和瘙痒,异物的感觉不适被问卷调查评估,和患者检查结膜充血。的细胞学表现,印象结膜是评估。两组中均有类似的症状。主观症状显著改变发红。在研究期间的相关在两组patient-reported发红,最高的30天。时间并没有改变时间和相似两组。随着时间的增加与唯一的两组组间显著差异在90天bimatoprost组(高)。观察结膜充血为最常见的副作用bimatoprost travoprost。泪膜功能没有受到这些影响药物在细胞学改变。

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