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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Hypertonic 15 sodium pyruvate offers no initial resuscitation advantage compared with 8 hypertonic NACl in sheep with multiple hemorrhages.
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Hypertonic 15 sodium pyruvate offers no initial resuscitation advantage compared with 8 hypertonic NACl in sheep with multiple hemorrhages.

机译：高渗丙酮酸钠并没有提供初始的15复苏优势这一比例为8高渗氯化钠与多个羊出血。

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摘要

Initial fluid resuscitation of hemorrhagic shock might be enhanced by the infusion of monocarboxylate-energy substrates. We evaluated hemodynamics, metabolism, and fluid dynamics for initial resuscitation of hemorrhage using small volume 15% sodium pyruvate solution (HPY) compared with osmotically matched 8% hypertonic saline (HS). Instrumented conscious sheep were hemorrhaged 25 mL/kg at time zero through 15 min (T0-T15) and 5 mL/kg for 5 min at T50 to T55 and T70 to T75. Fluid resuscitation from T30 to T180 was performed by a computer-controlled closed-loop system, which titrated infusion rate to a mean arterial pressure of 90 mmHg. Initial infusion was 4 mL/kg of either HPY or HS, followed by the administration of lactated Ringer. Both HPY and HS restored cardiac index similarly. The lactate/pyruvate ratio was used to assess metabolic debt and was significantly higher (T180), whereas oxygen delivery was significantly lower (T120) with HPY versus HS. Total fluid administered was similar, with 43.7 +/- 6.2 mL/kg for HPY and 39.4 +/- 6.8 mL/kg for HS. Plasma volume was similarly increased and approached baseline values for both groups. Initial resuscitation with small volume HPY offered no hemodynamic or metabolic advantage compared with small volume HS when the fluids were infused to an end point pressure.
机译：最初的出血性休克液体复苏可能是增强的注入monocarboxylate-energy基质。血液动力学、代谢和流体动力学使用小的初始复苏出血卷15%丙酮酸钠溶液(HPY)相比之下,osmotically匹配8%高渗盐水(HS)。狂砍25毫升/公斤在0到15分钟的时间(T0-T15)和5毫升/公斤T50套T55型和5分钟T70, T75。血压得到较好的控制是由计算机控制的吗闭环系统,滴定注入率平均动脉压90毫米汞柱。输液是4毫升/公斤HPY或者海关,其次是乳酸林格液的管理铃声。类似的。评估代谢债务和明显高(T180),而氧气交付显著降低(T120) HPY和海关。总液体管理类似,43.7+ / - 6.2毫升/公斤HPY为39.4 + / - 6.8毫升/公斤海关。接近两组的基线值。初始体积小HPY复苏没有提供血流动力学和代谢优势相比之下,体积小HS当液体输注结束点压力。

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